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Otman, Otman; Boullanger, Paul; Drockenmuller, Eric; Hamaide, Thierry

New amphiphilic glycopolymers by click functionalization of random copolymers – application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin A lectin

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  • Media type: E-Article
  • Title: New amphiphilic glycopolymers by click functionalization of random copolymers – application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin A lectin
  • Contributor: Otman, Otman; Boullanger, Paul; Drockenmuller, Eric; Hamaide, Thierry
  • Published: Beilstein Institut, 2010
  • Published in: Beilstein Journal of Organic Chemistry, 6 (2010)
  • Language: English
  • DOI: 10.3762/bjoc.6.58
  • ISSN: 1860-5397
  • Keywords: Organic Chemistry
  • Origination:
  • Footnote:
  • Description: Glycopolymers with mannose units were readily prepared by click chemistry of an azido mannopyranoside derivative and a poly(propargyl acrylate-co-N-vinyl pyrrolidone). These glycopolymers were used as polymer surfactants, in order to obtain glycosylated polycaprolactone nanoparticles. Optimum stabilization for long time storage was achieved by using a mixture of glycopolymers and the non-ionic triblock copolymer Pluronic® F-68. The mannose moieties are accessible at the surface of nanoparticles and available for molecular recognition by concanavalin A lectin. Interaction of mannose units with the lectin were evaluated by measuring the changes in nanoparticles size by dynamic light scattering in dilute media.
  • Access State: Open Access