• Medientyp: E-Book; Hochschulschrift
  • Titel: Modelling schizophrenia endophenotypes by overexpression of Neuregulin-1 isoforms in transgenic mice
  • Beteiligte: Soto-Bernardini, Maria Clara [VerfasserIn]; Schwab, Markus [AkademischeR BetreuerIn]; Brose, Nils [GutachterIn]; Marquardt, Till [GutachterIn]
  • Erschienen: Göttingen, 2017
  • Umfang: 1 Online-Ressource; Illustrationen, Diagramme
  • Sprache: Englisch
  • Identifikator:
  • Entstehung:
  • Schlagwörter: Hochschulschrift
  • Beschreibung: Neuregulin 1 (NRG1) is the best characterized member of a family of epidermal growth factor (EGF)-like domain containing proteins that serve as ligands for tyrosine kinase receptors of the ErbB family. NRG1 and its main receptor in the brain, ErbB4, have been involved in neural development, neurotransmission and synaptic plasticity. Additionally, NRG1 isoform-specific expression patterns in the brain have been described, but isoform-specific functions remain unclear. Nrg1 is a robustly associated schizophrenia susceptibility gene in many populations. Examination of blood cells and post mort...
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  • Zugangsstatus: Freier Zugang