Mattern, Kai
[Verfasser:in];
Trotha, Jakob von
[Verfasser:in];
Erfle, Peer
[Verfasser:in];
Köster, Reinhard
[Verfasser:in];
Dietzel, Andreas
[Verfasser:in]
NeuroExaminer: an all-glass microfluidic device for whole-brain in vivo imaging in zebrafish
- [Online-Ausgabe]
Beschreibung:
While microfluidics enables chemical stimuli application with high spatio-temporal precision, light-sheet microscopy allows rapid imaging of entire zebrafish brains with cellular resolution. Both techniques, however, have not been combined to monitor whole-brain neural activity yet. Unlike conventional microfluidics, we report here an all-glass device (NeuroExaminer) that is compatible with whole-brain in vivo imaging using light-sheet microscopy and can thus provide insights into brain function in health and disease.