Koßmann, Eugen Franz Josef
[VerfasserIn]
;
Schön, Michael
[AkademischeR BetreuerIn];
Wienands, Jürgen
[AkademischeR BetreuerIn];
Oppermann, Martin
[AkademischeR BetreuerIn]
Vascular Cell Adhesion Molecule-1 (VCAM-1) modulates plasticity of human melanoma cells
Beschreibung:
Malignant melanoma is by far the type of skin cancer with the highest mortality. As is the case for most cancers, metastasis is the major limiting factor determining therapeutic options and survival of the patients. Despite recent promising immunomodulatory therapies, the prognosis for patients with metastasized disease remains poor. The process of metastasis of solid tumors can generally be divided into a cascade consisting of local invasion around the primary tumor, intravasation, circulation in the bloodstream and finally extravasation with metastasis formation in distant organs. The int...