• Medientyp: E-Book; Hochschulschrift
  • Titel: Veränderungen an postsynaptischen Dornen in für die Suchtentwicklung relevanten Hirnregionen bei alkoholabhängigen Ratten
  • Beteiligte: Meier, Nils [VerfasserIn]; Bohlen und Halbach, Oliver von [AkademischeR BetreuerIn]; Asan, Esther [AkademischeR BetreuerIn]
  • Körperschaft: Universität Greifswald
  • Erschienen: Greifswald, 2020
  • Umfang: 1 Online-Ressource (PDF-Datei: 52 Seiten, 1298 Kilobyte); Illustrationen (teilweise farbig), Diagramme (teilweise farbig)
  • Sprache: Deutsch
  • Identifikator:
  • Entstehung:
  • Schlagwörter: Alkoholismus > Nucleus accumbens > Gyrus cinguli > Hirnrinde > Ratte
  • Beschreibung: Sucht, Alkohol, Neuronale Plastizität, Neuroanatomie, Hirnareal, Dornen, Gyrus cinguli, Infralimbischer Kortex, Nucleus accumbes, alcohol addiction, cingulate cortex, infralimbic cortex, nucleus accumbens, spine density, spines

    Alcohol ranks third among the risk factors for illness and premature death in Europe after tobacco and high blood pressure. The excessive consumption of alcohol is often caused by an alcohol addiction, which is very difficult for those affected to overcome. One of the reasons for this is that the effect of the therapeutic measures used to combat this addiction is very limited. To develop new and better therapies, it is first necessary to improve the understanding of the processes and relationships that are decisive for the development of addiction. The central nervous system of humans plays a major role in this. In this work, certain brain regions that are known to be associated with the development of an addiction were examined for changes due to alcohol addiction. Therefore, rats were first made alcohol dependent through chronic intermittent exposure to alcohol, then the brains were removed and colored by Golgi impregnation. Subsequently, nerve cell processes (dendrites) and their portals of entry for information (spines) from the cingulate gyrus, nucleus accumbens and infralimbic cortex were recorded three-dimensionally using light microscopy and reconstructed on the computer. These reconstructions were then analyzed for spine density (spines / μm dendrite length), spine length and spine diameter. A significantly higher spine density in the cingulate gyrus and a significantly lower spine density in the nucleus accumbens of the animals exposed to alcohol were found in ...
  • Anmerkungen: Literaturverzeichnis: Seite 37-45
  • Zugangsstatus: Freier Zugang