Likelihood of post-COVID condition in people with hybrid immunity: data from the German National Cohort (NAKO)

Medientyp: E-Artikel

Titel: Likelihood of post-COVID condition in people with hybrid immunity : data from the German National Cohort (NAKO)

Beteiligte: Mikolajczyk, Rafael [Verfasser:in]; Diexer, Sophie [Verfasser:in]; Klee, Bianca [Verfasser:in]; Pfrommer, Laura [Verfasser:in]; Purschke, Oliver [Verfasser:in]; Fricke, Julia [Verfasser:in]; Ahnert, Peter [Verfasser:in]; Gabrysch, Sabine [Verfasser:in]; Gottschick, Cornelia [Verfasser:in]; Bohn, Barbara [Verfasser:in]; Brenner, Hermann [Verfasser:in]; Buck, Christoph [Verfasser:in]; Castell, Stefanie [Verfasser:in]; Gastell, Sylvia [Verfasser:in]; Greiser, Karin Halina [Verfasser:in]; Harth, Volker [Verfasser:in]; Heise, Jana-Kristin [Verfasser:in]; Holleczek, Bernd [Verfasser:in]; Kaaks, Rudolf [Verfasser:in]; Keil, Thomas [Verfasser:in]; Krist, Lilian [Verfasser:in]; Leitzmann, Michael [Verfasser:in]; Lieb, Wolfgang [Verfasser:in]; Meinke-Franze, Claudia [Verfasser:in]; Michels, Karin B. [Verfasser:in]; Velásquez, Ilais Moreno [Verfasser:in]; Obi, Nadia [Verfasser:in]; Panreck, Leo [Verfasser:in]; Peters, Annette [Verfasser:in]; Pischon, Tobias [Verfasser:in]; Schikowski, Tamara [Verfasser:in]; Schmidt, Börge [Verfasser:in]; Standl, Marie [Verfasser:in]; Stang, Andreas [Verfasser:in]; Völzke, Henry [Verfasser:in]; Weber, Andrea [Verfasser:in]; Zeeb, Hajo [Verfasser:in]; Karch, André [Verfasser:in]

Erschienen: August 2024

Sprache: Englisch

DOI: 10.1016/j.jinf.2024.106206

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Schlagwörter: Hybrid immunity ; Post-COVID-19 condition ; Reinfection ; SARS-CoV-2 ; Vaccination

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Beschreibung: Objectives - The risk of Post-COVID-19 condition (PCC) under hybrid immunity remains unclear. - Methods - Using data from the German National Cohort (NAKO Gesundheitsstudie), we investigated risk factors for self-reported post-infection symptoms (any PCC is defined as having at least one symptom, and high symptom burden PCC as having nine or more symptoms). - Results - Sixty percent of 109,707 participants reported at least one previous SARS-CoV-2 infection; 35% reported having had any symptoms 4-12 months after infection; among them 23% reported nine or more symptoms. Individuals, who did not develop PCC after their first infection, had a strongly reduced risk for PCC after their second infection (50%) and a temporary risk reduction, which waned over 9 months after the preceding infection. The risk of developing PCC strongly depended on the virus variant. Within variants, there was no effect of the number of preceding vaccinations, apart from a strong protection by the fourth vaccination compared to three vaccinations for the Omicron variant (odds ratio = 0.52; 95% confidence interval 0.45-0.61). - Conclusions - Previous infections without PCC and a fourth vaccination were associated with a lower risk of PCC after a new infection, indicating diminished risk under hybrid immunity. The two components of risk reduction after a preceding infection suggest different immunological mechanisms.

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