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Medientyp:
Buch
Titel:
The eukaryotic replisome
:
a guide to protein structure and function
Enthält:
Composition and Dynamics of the Eukaryotic Replisome: A Brief Overview
/ Stuart MacNeill
Evolutionary Diversification of Eukaryotic DNA Replication Machinery
/ Stephen J. Aves, Yuan Liu and Thomas A. Richards
The Origin Recognition Complex: A Biochemical and Structural View
/ Huilin Li and Bruce Stillman
Archaeal Orc1/Cdc6 Proteins
/ Stephen D. Bell
Cdt1 and Geminin in DNA Replication Initiation
/ Christophe Caillat and Anastassis Perrakis
MCM Structure and Mechanics: What We Have Learned from Archaeal MCM
/ Ian M. Slaymaker and Xiaojiang S. Chen
The Eukaryotic Mcm2-7 Replicative Helicase
/ Sriram Vijayraghavan and Anthony Schwacha
The GINS Complex: Structure and Function
/ Katsuhiko Kamada
The Pol [alpha]-Primase Complex
/ Luca Pellegrini
The Structure and Function of Replication Protein A in DNA Replication
/ Aishwarya Prakash and Gloria E.O. Borgstahl
Structural Biology of Replication Initiation Factor Mcm10
/ Wenyue Du, Melissa E. Stauffer and Brandt F. Eichman
Structure and Function of Eukaryotic DNA Polymerase [delta]
/ Tahir H. Tahirov
DNA Polymerase [epsilon]
/ Matthew Hogg and Erik Johansson
The RFC Clamp Loader: Structure and Function
/ Nina Y. Yao and Mike O'Donnell
PCNA Structure and Function: Insights from Structures of PCNA Complexes and Post-translationally Modified PCNA
/ Lynne M. Dieckman, Bret D. Freudenthal and M. Todd Washington
The Wonders of Flap Endonucleases: Structure, Function, Mechanism and Regulation
/ L. David Finger, John M. Atack, Susan Tsutakawa, Scott Classen and John Tainer, et al.
DNA Ligase I, the Replicative DNA Ligase
/ Timothy R.L. Howes and Alan E. Tomkinson.
Beschreibung:
High-fidelity chromosomal DNA replication underpins all life on the planet. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Building on recent exciting advances in protein structure determination, the book will take the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosome replication and provide an invaluable source of information, ideas and .. --