• Medientyp: E-Book; Hochschulschrift
  • Titel: Einflussnahme von TGFβ auf die Strahlensensibilität lymphoblastoider Zellen
  • Weitere Titel: Nebentitel: Influence of TGFβ on the radiosensibility of lymphoblastiod cells
  • Beteiligte: Springer, Katarina [VerfasserIn]; Wolff, Hendrik [Betreuer]; Gaedcke, Jochen [Gutachter]; Meyer, Thomas [Gutachter]
  • Erschienen: 2015
  • Umfang: Online Ressource
  • Sprache: Deutsch
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  • Entstehung:
  • Schlagwörter: Hochschulschrift
  • Beschreibung: In this thesis 48 commercially purchased lymphoblastoid cell lines (LCLs) were used to investigate the effects of 1771 gene polymorphisms out of 23 candidate genes on genomic damages following various treatments. Therefore the LCLs were either incubated with 5 ng/ml TGFβ1, exposed to irradiation of 3 Gy or underwent a combined treatment (5 ng/ml TGFβ1 16 hours before 3 Gy irradiation) and were compared to an untreated sample. After an incubation period of 28 hours at 37°C and 5 % CO2 the micronucleus test was performed to make the chromosomal damages visible under the microscope. 14 cell li...
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  • Zugangsstatus: Freier Zugang