Combined Prospective Seroconversion and PCR Data of Selected Cohorts Indicate a High Rate of Subclinical SARS-CoV-2 Infections—an Open Observational Study in Lower Saxony, Germany

Medientyp: Sonstige Veröffentlichung; E-Artikel

Titel: Combined Prospective Seroconversion and PCR Data of Selected Cohorts Indicate a High Rate of Subclinical SARS-CoV-2 Infections—an Open Observational Study in Lower Saxony, Germany

Beteiligte: Jonczyk, Rebecca [Verfasser:in]; Stanislawski, Nils [Verfasser:in]; Seiler, Lisa K. [Verfasser:in]; Blume, Holger [Verfasser:in]; Heiden, Stefanie [Verfasser:in]; Lucas, Henning [Verfasser:in]; Sarikouch, Samir [Verfasser:in]; Pott, Philipp-Cornelius [Verfasser:in]; Stiesch, Meike [Verfasser:in]; Hauß, Corinna [Verfasser:in]; Saletti, Giulietta [Verfasser:in]; González-Hernández, Mariana [Verfasser:in]; Kaiser, Franziska Karola [Verfasser:in]; Rimmelzwaan, Guus [Verfasser:in]; Osterhaus, Albert [Verfasser:in]; Blume, Cornelia [Verfasser:in]

Erschienen: Birmingham, Ala. : ASM, 2022

Ausgabe: published Version

Sprache: Englisch

DOI: https://doi.org/10.15488/12234; https://doi.org/10.1128/spectrum.01512-21

Schlagwörter: subclinical cases ; neutralizing antibodies ; working groups ; SARS-CoV-2 antibody screening ; antibody screening tests ; COVID-19 ; PCR

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Beschreibung: Despite lockdown measures, intense symptom-based PCR, and antigen testing, the SARS-CoV-2 pandemic spread further. In this open observational study conducted in Lower Saxony, Germany, voluntary SARS-CoV-2 PCR tests were performed from April 2020 until June 2021, supported by serum antibody testing to prove whether PCR testing in subjects with none or few symptoms of COVID-19 is a suitable tool to manage the pandemic. In different mobile stations, 4,817 subjects from three different working fields participated in the PCR testing. Serum antibody screening using the SARS-CoV-2 ViraChip IgG (Viramed, Germany) and the Elecsys Anti-SARS-CoV-2 assay (Roche, Germany) was performed alongside virus neutralization testing. Subjects were questioned regarding comorbidities and COVID-19 symptoms. Fifty-one subjects with acute SARS-CoV-2 infection were detected of which 31 subjects did not show any symptoms possibly characteristic for COVID-19. An additional 37 subjects reported a previous SARS-CoV-2 infection (total prevalence 1.82%). Seroconversion was discovered in 58 subjects with known SARS-CoV-2 infection and in 58 subjects that never had a positive PCR test. The latter had a significantly lower Charlson Comorbidity Index, and one third of them were asymptomatic. In 50% of all seroconverted subjects, neutralizing serum antibodies (NAbs) were detectable in parallel to N/S1 (n = 16) or N/S1/S2 antigen specific antibodies (n = 40) against SARS-CoV-2. NAb titers decreased within 100 days after PCR-confirmed SARS-CoV-2 acute infection by at least 2.5-fold. A relatively high rate of subclinical SARS-CoV-2 infections may contribute to the spread of SARS-CoV-2, suggesting that in addition to other intervention strategies, systematic screening of asymptomatic persons by PCR testing may significantly enable better pandemic control.

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Combined Prospective Seroconversion and PCR Data of Selected Cohorts Indicate a High Rate of Subclinical SARS-CoV-2 Infections—an Open Observational Study in Lower Saxony, Germany - [published Version]

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