• Medientyp: E-Artikel; Sonstige Veröffentlichung
  • Titel: Reproducibility of three different cardiac T2-mapping sequences at 1.5T and impact of cofactors on T2-relaxation times
  • Beteiligte: Baessler, Bettina [VerfasserIn]; Schaarschmidt, Frank [VerfasserIn]; Schnackenburg, Bernhard [VerfasserIn]; Stehning, Christian [VerfasserIn]; Giolda, Agathe D. [VerfasserIn]; Maintz, David [VerfasserIn]; Bunck, Alexander [VerfasserIn]
  • Erschienen: London : Biomed Central Ltd, 2015
  • Erschienen in: Journal of Cardiovascular Magnetic Resonance 17 (2015), Suppl. 1
  • Sprache: Englisch
  • DOI: https://doi.org/10.15488/519; https://doi.org/10.1186/1532-429X-17-S1-W12
  • ISSN: 1532-429X
  • Schlagwörter: radiology ; T2-mapping
  • Beschreibung: Background: The high interindividual variability of myocardial T2 relaxation times appears to be one of the main challenges for the clinical application of cardiac T2-mapping. This study therefore aimed to evaluate potential underlying causes for this variability, analyzing the reproducibility of three different cardiac T2-mapping sequences and evaluating the influence of cofactors on T2 relaxation times. Methods: 30 healthy volunteers were examined three times on a clinical 1.5T scanner (scan 1: in the morning; scan 2: in the evening of the same day; scan 3: in the evening 2-3 weeks later). In each examination three different T2-mapping sequences were acquired at three slices in short axis view: Multi Echo Spin Echo (MESE), T2-prepared balanced Steady State Free Precession (T2prep; [1]) and Gradient Spin Echo (GraSE). Repeated measurements were performed for T2prep and GraSE. Segmented T2-maps were generated for each slice according to the AHA 17-segment model. Intra- and inter-observer reproducibility was tested in a subgroup of 10 randomly selected subjects, where manual ROIs were drawn independently to measure T2 values of each segment blinded to the other results. Results: Overall, we observed no systematic difference of T2 times due to diurnal effects and on long-term analysis. Differentiated analysis of variance components for all sequences, however, revealed a greater variance of T2 times over multiple time points than for repeated measurements within the same scan. Our study revealed a low intra-observer and inter-observer variability of manual ROI-definition and the acquired T2 times for each sequence. The coefficients of variation and intraclass correlation coefficients for intra-observer variability were: 1.3% and 0.89 for T2prep, 1.5% and 0.93 for GraSE, 3.1% and 0.83 for MESE; and for inter-observer variability: 3.3% and 0.66 for T2prep, 2.0% and 0.83 for GraSE, 3.6% and 0.77 for MESE. With respect to the influence of potential cofactors on T2 times, we observed a negative effect of the cofactor ...
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