Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury

Medientyp: E-Artikel

Titel: Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury

Beteiligte: Beyer, Leonie [Verfasser:in]; Nitschmann, Alexander [Verfasser:in]; Hammes, Jochen [Verfasser:in]; Barbe, Michael T. [Verfasser:in]; Onur, Özgür [Verfasser:in]; Jessen, Frank [Verfasser:in]; Saur, Dorothee [Verfasser:in]; Schroeter, Matthias L. [Verfasser:in]; Rumpf, Jost-Julian [Verfasser:in]; Rullmann, Michael [Verfasser:in]; Schildan, Andreas [Verfasser:in]; Patt, Marianne [Verfasser:in]; Barthel, Henryk [Verfasser:in]; Neumaier, Bernd [Verfasser:in]; Barret, Olivier [Verfasser:in]; Madonia, Jennifer [Verfasser:in]; Russell, David S. [Verfasser:in]; Stephens, Andrew W. [Verfasser:in]; Roeber, Sigrun [Verfasser:in]; Herms, Jochen [Verfasser:in]; Bötzel, Kai [Verfasser:in]; Levin, Johannes [Verfasser:in]; Classen, Joseph [Verfasser:in]; van Eimeren, Thilo [Verfasser:in]; [...]

Erschienen: Springer-Verl., 2020

Sprache: Englisch

DOI: https://doi.org/10.1007/s00259-020-04788-w

ISSN: 1619-7070; 1619-7089; 1432-105X; 0340-6997

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Beschreibung: PurposeSecond-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [18F]PI-2620 as a potential substitute for [18F]fluorodeoxyglucose ([18F]FDG).MethodsTwenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer’s disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkinson’s disease, multi-system atrophy, Parkinson's disease, frontotemporal dementia) and received a dynamic [18F]PI-2620 tau-PET (0–60 min p.i.) and static [18F]FDG-PET (30–50 min p.i.). Regional standardized uptake value ratios of early-phase images (single frame SUVr) and the blood flow estimate (R1) of [18F]PI-2620-PET were correlated with corresponding quantification of [18F]FDG-PET (global mean/cerebellar normalization). Reduced tracer uptake in cortical target regions was also interpreted visually using 3-dimensional stereotactic surface projections by three more and three less experienced readers. Spearman rank correlation coefficients were calculated between early-phase [18F]PI-2620 tau-PET and [18F]FDG-PET images for all cortical regions and frequencies of disagreement between images were compared for both more and less experienced readers.ResultsHighest agreement with [18F]FDG-PET quantification was reached for [18F]PI-2620-PET acquisition from 0.5 to 2.5 min p.i. for global mean (lowest R = 0.69) and cerebellar scaling (lowest R = 0.63). Correlation coefficients (summed 0.5–2.5 min SUVr & R1) displayed strong agreement in all cortical target regions for global mean (RSUVr 0.76, RR1 = 0.77) and cerebellar normalization (RSUVr 0.68, RR1 = 0.68). Visual interpretation revealed high regional correlations between ...

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