Chen, Xiangliang
[Verfasser:in];
Laurent, Sarah
[Verfasser:in];
Onur, Oezguer A.
[Verfasser:in];
Kleineberg, Nina N.
[Verfasser:in];
Fink, Gereon R.
[Verfasser:in];
Schweitzer, Finja
[Verfasser:in];
Warnke, Clemens
[Verfasser:in]
A systematic review of neurological symptoms and complications of COVID-19
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Medientyp:
E-Artikel
Titel:
A systematic review of neurological symptoms and complications of COVID-19
Beteiligte:
Chen, Xiangliang
[Verfasser:in];
Laurent, Sarah
[Verfasser:in];
Onur, Oezguer A.
[Verfasser:in];
Kleineberg, Nina N.
[Verfasser:in];
Fink, Gereon R.
[Verfasser:in];
Schweitzer, Finja
[Verfasser:in];
Warnke, Clemens
[Verfasser:in]
Erschienen:
Springer85301, 2021
Erschienen in:Journal of neurology 268, 392–402 (2021). doi:10.1007/s00415-020-10067-3
Anmerkungen:
Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
Beschreibung:
ObjectiveTo study the frequency of neurological symptoms and complications in COVID-19 patients in a systematic review of the literature.MethodsRelevant studies were identified through electronic explorations of PubMed, medRxiv, and bioRxiv. Besides, three Chinese databases were searched. A snowballing method searching the bibliographies of the retrieved references was applied to identify potentially relevant articles. Articles published within 1 year prior to April 20th, 2020, were screened with no language restriction imposed. Databases were searched for terms related to SARS-CoV-2/COVID-19 and neurological manifestations, using a pre-established protocol registered on the International Prospective Register of Systematic Reviews database (ID: CRD42020187994).ResultsA total of 2441 articles were screened for relevant content, of which 92 full-text publications were included in the analyses of neurological manifestations of COVID-19. Headache, dizziness, taste and smell dysfunctions, and impaired consciousness were the most frequently described neurological symptoms, the latter more often among patients with a severe or critical disease course. To date, only smaller cohort studies or single cases have reported cerebrovascular events, seizures, meningoencephalitis, and immune-mediated neurological diseases, not suitable for quantitative analysis.ConclusionThe most frequent neurological symptoms reported in association with COVID-19 are non-specific for the infection with SARS-CoV-2. Although SARS-CoV-2 may have the potential to gain direct access to the nervous system, so far, SARS-CoV-2 was detected in the cerebrospinal fluid in two cases only. Standardized international registries are needed to clarify the clinical relevance of the neuropathogenicity of SARS-CoV-2 and to elucidate a possible impact of SARS-CoV-2 infection on common neurological disease, such as Alzheimer’s, Parkinson’s disease or multiple sclerosis.