LABENZ, J.;
TILLENBURG, B.;
WEISMÜLLER, J.;
LÜTKE, A.;
STOLTE, M.
Efficacy and tolerability of a one‐week triple therapy consisting of pantoprazole, clarithromycin and amoxycillin for cure of Helicobacter pylori infection in patients with duodenal ulcer
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E-Artikel
Titel:
Efficacy and tolerability of a one‐week triple therapy consisting of pantoprazole, clarithromycin and amoxycillin for cure of Helicobacter pylori infection in patients with duodenal ulcer
Beschreibung:
<jats:p> <jats:italic>Background</jats:italic>: Previous studies have shown that one‐week triple therapy consisting of omeprazole, clarithromycin and amoxycillin may cure <jats:italic>Helicobacter pylori</jats:italic> infection in the vast majority of patients. The present study was designed to test the hypothesis that a triple therapy with pantoprazole, clarithromycin and amoxycillin cures the infection in 80% of duodenal ulcer patients infected with <jats:italic>H. pylori</jats:italic>.</jats:p><jats:p> <jats:italic>Methods</jats:italic>: In an open two‐centre study, 60 duodenal ulcer patients were treated with pantoprazole 40 mg b.d., clarithromycin 500 mg b.d. and amoxycillin 1 g b.d. for 1 week. During the second week patients received pantoprazole 40 mg once in the morning. We assessed <jats:italic>H. pylori</jats:italic> infection before treatment and 4 weeks after cessation of the study medication by a rapid urease test, histology after Warthin–Starry stain and a <jats:sup>13</jats:sup>C‐urea breath test.</jats:p><jats:p> <jats:italic>Results</jats:italic>: Sixty patients (42 males, mean age 47.4 years) entered the trial. All patients were infected with <jats:italic>H. pylori</jats:italic>. One patient was withdrawn from the study because of allergy to penicillin and six patients were protocol violators. <jats:italic>H. pylori</jats:italic> infection was cured in 47 out of 53 patients who completed the trial according to the protocol (89%; 95% CI: 80–97%) and in 49 of 60 patients included in the trial (82%; 95% CI: 72–92%). Four weeks after the last administration of study drugs, 55 out of 60 ulcers had healed (92%). Twenty‐nine patients reported 51 adverse events that were mostly mild to moderate.</jats:p><jats:p> <jats:italic>Conclusions</jats:italic>: One‐week triple therapy consisting of pantoprazole, clarithromycin and amoxycillin is a simple and effective approach to the cure of <jats:italic>H. pylori</jats:italic> infection in patients with duodenal ulcer. In those patients who took the drugs as prescribed the <jats:italic>H. pylori</jats:italic> cure rate was 89%, with the lower 95% confidence limit being 80%.</jats:p>