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Wolpaw, Adam J.; Grossmann, Liron D.; Dessau, Jessica L.; Dong, May M.; Aaron, Bailey J.; Brafford, Patricia A.; Volgina, Darya; Pascual-Pasto, Guillem; Rodriguez-Garcia, Alba; Uzun, Yasin; Arsenian-Henriksson, Marie; Powell, Daniel J.; Bosse, Kristopher R.; Kossenkov, Andrew; Tan, Kai; Hogarty, Michael D.; Maris, John M.; Dang, Chi V.

Epigenetic state determines inflammatory sensing in neuroblastoma

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  • Medientyp: E-Artikel
  • Titel: Epigenetic state determines inflammatory sensing in neuroblastoma
  • Beteiligte: Wolpaw, Adam J.; Grossmann, Liron D.; Dessau, Jessica L.; Dong, May M.; Aaron, Bailey J.; Brafford, Patricia A.; Volgina, Darya; Pascual-Pasto, Guillem; Rodriguez-Garcia, Alba; Uzun, Yasin; Arsenian-Henriksson, Marie; Powell, Daniel J.; Bosse, Kristopher R.; Kossenkov, Andrew; Tan, Kai; Hogarty, Michael D.; Maris, John M.; Dang, Chi V.
  • Erschienen: Proceedings of the National Academy of Sciences, 2022
  • Erschienen in: Proceedings of the National Academy of Sciences, 119 (2022) 6
  • Sprache: Englisch
  • DOI: 10.1073/pnas.2102358119
  • ISSN: 1091-6490; 0027-8424
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Significance Making immunotherapy more widely effective requires improved understanding of the pathways that regulate the interactions between tumor and immune cells. This work identified a previously unappreciated difference in these pathways between heterogenous epigenetic states that coexist in neuroblastoma. The generally rarer mesenchymal subpopulation has more active inflammatory sensing and signaling, revealing a potential immunologic vulnerability of these chemotherapy-resistant cells.
  • Zugangsstatus: Freier Zugang