• Medientyp: E-Artikel
  • Titel: RNA-bound PGC-1α controls gene expression in liquid-like nuclear condensates
  • Beteiligte: Pérez-Schindler, Joaquín; Kohl, Bastian; Schneider-Heieck, Konstantin; Leuchtmann, Aurel B.; Henríquez-Olguín, Carlos; Adak, Volkan; Maier, Geraldine; Delezie, Julien; Sakoparnig, Thomas; Vargas-Fernández, Elyzabeth; Karrer-Cardel, Bettina; Ritz, Danilo; Schmidt, Alexander; Hondele, Maria; Jensen, Thomas E.; Hiller, Sebastian; Handschin, Christoph
  • Erschienen: Proceedings of the National Academy of Sciences, 2021
  • Erschienen in: Proceedings of the National Academy of Sciences
  • Sprache: Englisch
  • DOI: 10.1073/pnas.2105951118
  • ISSN: 0027-8424; 1091-6490
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  • Beschreibung: <jats:title>Significance</jats:title> <jats:p>The function of tissues is controlled by complex biological processes, in which transcriptional mechanisms play a fundamental role. The transcriptional coactivator PGC-1α is a prototypical regulator of adaptive responses evoked by environmental and internal cues (e.g. exercise-adaptation in skeletal muscle). Here, we found that PGC-1α-RNA–binding is central to assemble multiprotein complexes controlling gene transcription. Interestingly, PGC-1α-RNA–binding also regulates chromatin recruitment in transcriptionally active liquid-like nuclear condensates. Collectively, our findings unravel mechanistic insights into the regulation of complex transcriptional networks by PGC-1α, which we demonstrate to be essential to enhance the expression of key genes controlling skeletal muscle oxidative metabolism.</jats:p>
  • Zugangsstatus: Freier Zugang