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Medientyp:
E-Artikel
Titel:
Adipose expression of miR-130b and miR-17-5p with wasting, cardiovascular event and mortality in advanced chronic kidney disease patients
Beteiligte:
Chan, Gordon Chun-Kau;
Than, Win Hlaing;
Kwan, Bonnie Ching-Ha;
Lai, Ka-Bik;
Chan, Ronald Cheong-Kin;
Ng, Jack Kit-Chung;
Chow, Kai-Ming;
Cheng, Phyllis Mei-Shan;
Law, Man-Ching;
Leung, Chi-Bon;
Li, Philip Kam-Tao;
Szeto, Cheuk-Chun
Erschienen:
Oxford University Press (OUP), 2022
Erschienen in:
Nephrology Dialysis Transplantation, 37 (2022) 10, Seite 1935-1943
Sprache:
Englisch
DOI:
10.1093/ndt/gfab287
ISSN:
0931-0509;
1460-2385
Entstehung:
Anmerkungen:
Beschreibung:
ABSTRACT Background There are limited data on the association of adipose microRNA expression with body composition and adverse clinical outcomes in patients with advanced chronic kidney disease (CKD). We aimed to evaluate the association of adipose miR-130b and miR-17-5p expressions with body composition, functional state, cardiovascular outcome and mortality in incident dialysis patients. Methods We performed a single-center prospective cohort study. Patients who were planned for peritoneal dialysis were recruited. miR-130b and miR-17-5p expressions were measured from subcutaneous and pre-peritoneal fat tissue obtained during peritoneal dialysis catheter insertion. Body composition and physical function were assessed by bioimpedance spectroscopy and Clinical Frailty Scale. Primary outcome was 2-year survival. Secondary outcomes were 2-year technique survival and major adverse cardiovascular event (MACE) rate. Results Adipose expression of miR-130b and miR-17-5p correlated with parameters of muscle mass including intracellular water (miR-130b: r = 0.191, P = 0.02; miR-17-5p: r = 0.211, P = 0.013) and lean tissue mass (miR-17-5p: r = 0.176, P = 0.04; miR-17-5p: r = 0.176, P = 0.004). miR-130b expression predicted frailty significantly (P = 0.017). Adipose miR-17-5p expression predicted 2-year all-cause survival (P = 0.020) and technique survival (P = 0.036), while miR-130b expression predicted incidence of MACE (P = 0.015). Conclusions Adipose miR-130b and miR-17-5p expressions correlated with body composition parameters, frailty, and predicted cardiovascular events and mortality in advanced CKD patients.