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Chaix, Marie-Laure; Charreau, Isabelle; Pintado, Claire; Delaugerre, Constance; Mahjoub, Nadia; Cotte, Laurent; Capitant, Catherine; Raffi, François; Cua, Eric; Pialoux, Gilles; Tremblay, Cécile; Meyer, Laurence; Molina, Jean-Michel; Pintado, C; Loze, B; Delaugerre, C; Charbonneau, P; Gatey, C; Ponscarme, D; Penot, P; Niedbalski, L; Veron, R; Delgado, J; Dalle, E; [...]

Effect of On-Demand Oral Pre-exposure Prophylaxis With Tenofovir/Emtricitabine on Herpes Simplex Virus-1/2 Incidence Among Men Who Have Sex With Men: A Substudy of the ANRS IPERGAY Trial

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  • Medientyp: E-Artikel
  • Titel: Effect of On-Demand Oral Pre-exposure Prophylaxis With Tenofovir/Emtricitabine on Herpes Simplex Virus-1/2 Incidence Among Men Who Have Sex With Men: A Substudy of the ANRS IPERGAY Trial
  • Beteiligte: Chaix, Marie-Laure; Charreau, Isabelle; Pintado, Claire; Delaugerre, Constance; Mahjoub, Nadia; Cotte, Laurent; Capitant, Catherine; Raffi, François; Cua, Eric; Pialoux, Gilles; Tremblay, Cécile; Meyer, Laurence; Molina, Jean-Michel; Pintado, C; Loze, B; Delaugerre, C; Charbonneau, P; Gatey, C; Ponscarme, D; Penot, P; Niedbalski, L; Veron, R; Delgado, J; Dalle, E; [...]
  • Erschienen: Oxford University Press (OUP), 2018
  • Erschienen in: Open Forum Infectious Diseases
  • Sprache: Englisch
  • DOI: 10.1093/ofid/ofy295
  • ISSN: 2328-8957
  • Schlagwörter: Infectious Diseases ; Oncology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title> <jats:p>We evaluated the impact of on-demand oral tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) for pre-exposure prophylaxis (PrEP) on herpes simplex virus (HSV)-1/2 incidence among men who have sex with men (MSM) enrolled in the ANRS IPERGAY trial. Serum samples were tested at baseline and at the last visit for HSV-1/2 antibodies. Overall HSV-1 incidence was 11.7 per 100 person-years; 16.2 and 7.8 per 100 person-years in the TDF/FTC and placebo arm, respectively (P = .19). Overall HSV-2 incidence was 7.6 per 100 person-years; 8.1 and 7.0 per 100 person-years in the TDF/FTC and placebo arm, respectively (P = .75). On-demand oral PrEP with TDF/FTC failed to reduce HSV-1/2 incidence in this population.</jats:p>
  • Zugangsstatus: Freier Zugang