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Gomez Rivas, Juan ; Nicoletti, Rossella ; Ibáñez, Laura ; Steinbeisser, Carl ; de Meulder, Bertrand ; Golozar, Asieh ; Axelsson, Susan Evans ; Snijder, Robert ; Bjartell, Anders ; Cornford, Philip ; Van Hemelrijck, Mieke ; Beyer, Katharina ; Willemse, Peter-Paul ; Murtola, Teemu ; Roobol, Monique J. ; Moreno-Sierra, Jesús ; Campi, Riccardo ; Gacci, Mauro ; Mottet, Nicolas ; Merseburger, Axel ; Ndow, James

Research protocol to identify progression and death amongst patients with metastatic hormone-sensitive prostate cancer treated with available treatments: PIONEER IMI’s “big data for better outcomes” program

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  • Medientyp: E-Artikel
  • Titel: Research protocol to identify progression and death amongst patients with metastatic hormone-sensitive prostate cancer treated with available treatments: PIONEER IMI’s “big data for better outcomes” program
  • Beteiligte: Gomez Rivas, Juan ; Nicoletti, Rossella ; Ibáñez, Laura ; Steinbeisser, Carl ; de Meulder, Bertrand ; Golozar, Asieh ; Axelsson, Susan Evans ; Snijder, Robert ; Bjartell, Anders ; Cornford, Philip ; Van Hemelrijck, Mieke ; Beyer, Katharina ; Willemse, Peter-Paul ; Murtola, Teemu ; Roobol, Monique J. ; Moreno-Sierra, Jesús ; Campi, Riccardo ; Gacci, Mauro ; Mottet, Nicolas ; Merseburger, Axel ; Ndow, James
  • Erschienen: Ovid Technologies (Wolters Kluwer Health), 2023
  • Erschienen in: International Journal of Surgery Protocols, 27 (2023) 3, Seite 122-129
  • Sprache: Englisch
  • DOI: 10.1097/sp9.0000000000000009
  • ISSN: 2468-3574
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Androgen deprivation therapy-based with or without first-generation anti-androgens, was the standard of care for patients with metastatic hormone-sensitive prostate cancer (mHSPC) for decades. However, the development of docetaxel chemotherapy and new androgen receptor-targeted agents, abiraterone acetate and prednisolone, apalutamide , enzalutamide and darolutamide (in combination with docetaxel chemotherapy) has proven that combination of treatments is more effective. Recently, intensification therapy, so-called “triplets”, have emerged in the armamentarium of mHSPC treatment. Metastatic disease is a clinical state that remains poorly understood. The optimal diagnostic and management of patients with mHSPC are changing thanks to the development of new imaging techniques and therapies. The primary objective of this study is to develop and validate a predictive model for the occurrence of symptomatic progression, initiation of new treatments and death amongst patients with mHSPC treated with one of the approved treatment plans, on characteristics present at admission.
  • Zugangsstatus: Freier Zugang