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Sormani, Maria Pia;
Salvetti, Marco;
Labauge, Pierre;
Schiavetti, Irene;
Zephir, Helene;
Carmisciano, Luca;
Bensa, Caroline;
De Rossi, Nicola;
Pelletier, Jean;
Cordioli, Cinzia;
Vukusic, Sandra;
Moiola, Lucia;
Kerschen, Philippe;
Radaelli, Marta;
Théaudin, Marie;
Immovilli, Paolo;
Casez, Olivier;
Capobianco, Marco;
Ciron, Jonathan;
Trojano, Maria;
Stankoff, Bruno;
Créange, Alain;
Tedeschi, Gioacchino;
Clavelou, Pierre;
[...]
DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France
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- Medientyp: E-Artikel
- Titel: DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France
- Beteiligte: Sormani, Maria Pia; Salvetti, Marco; Labauge, Pierre; Schiavetti, Irene; Zephir, Helene; Carmisciano, Luca; Bensa, Caroline; De Rossi, Nicola; Pelletier, Jean; Cordioli, Cinzia; Vukusic, Sandra; Moiola, Lucia; Kerschen, Philippe; Radaelli, Marta; Théaudin, Marie; Immovilli, Paolo; Casez, Olivier; Capobianco, Marco; Ciron, Jonathan; Trojano, Maria; Stankoff, Bruno; Créange, Alain; Tedeschi, Gioacchino; Clavelou, Pierre; [...]
- Erschienen: Wiley, 2021
- Erschienen in: Annals of Clinical and Translational Neurology
- Umfang: 1738-1744
- Sprache: Englisch
- DOI: 10.1002/acn3.51408
- ISSN: 2328-9503
- Schlagwörter: Neurology (clinical) ; General Neuroscience
- Zusammenfassung: <jats:title>Abstract</jats:title><jats:p>We evaluated the effect of DMTs on Covid‐19 severity in patients with MS, with a pooled‐analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid‐19 severity was assessed by multivariate ordinal‐logistic models and pooled by a fixed‐effect meta‐analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti‐CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, <jats:italic>p</jats:italic> < 0.001) with Covid‐19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, <jats:italic>p</jats:italic> = 0.047). This pooled‐analysis confirms an increased risk of severe Covid‐19 in patients on anti‐CD20 therapies and supports the protective role of interferon.</jats:p>
- Beschreibung: <jats:title>Abstract</jats:title><jats:p>We evaluated the effect of DMTs on Covid‐19 severity in patients with MS, with a pooled‐analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid‐19 severity was assessed by multivariate ordinal‐logistic models and pooled by a fixed‐effect meta‐analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti‐CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, <jats:italic>p</jats:italic> < 0.001) with Covid‐19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, <jats:italic>p</jats:italic> = 0.047). This pooled‐analysis confirms an increased risk of severe Covid‐19 in patients on anti‐CD20 therapies and supports the protective role of interferon.</jats:p>
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