Synthesis and 5‐HT2A, 5‐HT1A and α1‐Binding Affinities of 2‐[2‐Hydroxy‐3‐(pyridin‐3‐yl‐methyl)amino]‐, 2‐[2‐Hydroxy‐3‐(2‐pyridin‐2‐yl‐ethyl)amino]‐ and 2‐[2‐Hydroxy‐3‐(4‐N‐methyl‐piperazin‐1‐yl)‐amino]propoxybenzaldehyde‐O‐(substituted) Benzyl Oximes
Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
Medientyp:
E-Artikel
Titel:
Synthesis and 5‐HT2A, 5‐HT1A and α1‐Binding Affinities of 2‐[2‐Hydroxy‐3‐(pyridin‐3‐yl‐methyl)amino]‐, 2‐[2‐Hydroxy‐3‐(2‐pyridin‐2‐yl‐ethyl)amino]‐ and 2‐[2‐Hydroxy‐3‐(4‐N‐methyl‐piperazin‐1‐yl)‐amino]propoxybenzaldehyde‐O‐(substituted) Benzyl Oximes
Beschreibung:
<jats:title>Abstract</jats:title><jats:p>Some oxime ether‐substituted aryloxypropanolamines <jats:bold>3</jats:bold>‐<jats:bold>5</jats:bold>, structurally related to the active metabolite <jats:bold>2 </jats:bold>of sarpogrelate <jats:bold>1</jats:bold>, were synthesized and tested for their affinities at 5‐HT<jats:sub>2A</jats:sub> and 5‐HT<jats:sub>1A </jats:sub>serotoninergic receptors as well as at the α<jats:sub>1</jats:sub>‐adrenoceptor. The results show that the compounds possess, at least partially, the ability of the model compounds <jats:bold>1 </jats:bold>and<jats:bold> 2</jats:bold> to interact with the 5‐HT<jats:sub>2A</jats:sub>‐receptors; they have the same selectivity towards 5‐HT<jats:sub>2A</jats:sub> receptors <jats:italic>vs</jats:italic> α<jats:sub>1</jats:sub>‐adrenoceptors.</jats:p>