Beschreibung:
<jats:title>Abstract</jats:title><jats:sec><jats:title>Objectives</jats:title><jats:p>The aim is to assess the experience in the Netherlands using the Xposition S self‐apposing stent in complex coronary lesions in clinical practice.</jats:p></jats:sec><jats:sec><jats:title>Background</jats:title><jats:p>Treatment of complex coronary lesions could be accompanied with stent sizing difficulties and complications, particularly due to vessel overdilation or stent underexpansion. The self‐apposing feature of the Xposition S stent (STENTYS, Paris, France) supports good strut apposition in complex anatomies and allows for an increase in diameter after implantation.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>In this real‐world registry, data from patients treated with Xposition S in four Dutch clinical sites were prospectively collected and analyzed. Any patient suitable for implantation with Xposition S according to current recommendations was enrolled. Primary endpoint was major adverse cardiac events (MACE) at 1 year.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Between 2015 and 2018, data from 251 patients were collected. Clinical presentation was an acute coronary syndrome in majority of the patients (76.9%). Main angiographic indications were lesions in aneurysmatic or ectatic vessels (32.3%), thrombus containing lesions (13.1%), and bifurcation/left main stenosis (10.4%). Most of the target lesions (TLs) were classified as AHA/ACC Type C (53.6%). Despite lesion complexity, device was successfully implanted at TL in 96.8%. MACE rate, reported on patients having completed 1‐year follow‐up (<jats:italic>n</jats:italic> = 203), was 6.6%, with low rate of definite/probable stent thrombosis (1.0%).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>In clinical practice of several Dutch sites, STENTYS Xposition S showed good procedural results and low 1‐year clinical events rate, despite complex coronary anatomy.</jats:p></jats:sec>