Generation of CD28− cells from long-term-stimulated CD8+CD28+ T cells: a possible mechanism accounting for the increased number of CD8+CD28− T cells in HIV-1-infected patients
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Medientyp:
E-Artikel
Titel:
Generation of CD28− cells from long-term-stimulated CD8+CD28+ T cells: a possible mechanism accounting for the increased number of CD8+CD28− T cells in HIV-1-infected patients
Erschienen in:
Journal of Leukocyte Biology, 65 (1999) 5, Seite 641-648
Sprache:
Englisch
DOI:
10.1002/jlb.65.5.641
ISSN:
1938-3673;
0741-5400
Entstehung:
Anmerkungen:
Beschreibung:
Abstract According to CD28 molecule expression, CD8+ T cells can be classed as CD28bright, CD28dim, and CD28−. The CD28dim T cells were found to derive from mitogenic stimulated CD28− T cells but also from CD28bright T cells through a mechanism of CD28 down-modulation. Moreover, after prolonged in vitro interleukin-2 stimulation, clonal CD28bright cells showed a CD28dim expression before further evolution to a stable CD28− phenotype. This loss was concomitant with the disappearance of CD28 mRNA. A study of the cytokine production pattern revealed that CD28dim and CD28−T cell clones produced similar levels of type 1 and type 2 cytokines, which differed from those produced by the CD28bnght T cell clones. A high percentage of CD28dim and CD28− cells, with similarities in their cytokine production pattern, were found in the blood samples of HIV-infected patients, as compared to healthy donors. The CD28 down-modulation may account for the increased number of CD8+CD28− T cells in HIV-infected patients. J. Leukoc. Biol. 65: 641–648; 1999.