Synthetic route to isotopically labelled‐oxamate

Medientyp: E-Artikel
Titel: Synthetic route to isotopically labelled‐oxamate
Beteiligte: Siwek, Agata; Trotsko, Nazar; Wujec, Monika; Kamiński, Rafał; Paneth, Piotr
Erschienen: Wiley, 2011
Erschienen in: Journal of Labelled Compounds and Radiopharmaceuticals
Sprache: Englisch
DOI: 10.1002/jlcr.1876
ISSN: 0362-4803; 1099-1344
Schlagwörter: Organic Chemistry ; Spectroscopy ; Drug Discovery ; Radiology, Nuclear Medicine and imaging ; Biochemistry ; Analytical Chemistry
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Beschreibung: <jats:title>Abstract</jats:title><jats:p>Since none of the available methods was suitable for the synthesis of isotopically labelled oxamate, a new procedure has been developed in our laboratory, based on the known procedures, but with substantial modifications. The method is convenient and gives reproducibly 17% yield based on KCN used. The strategy is considered suitable for labelling oxamate with <jats:sup>15</jats:sup>N and <jats:sup>13</jats:sup>C or <jats:sup>14</jats:sup>C when starting with labelled KCN and can be easily modified for the synthesis of <jats:sup>18</jats:sup>O‐carbonyl‐labelled oxamate. Copyright © 2011 John Wiley & Sons, Ltd.</jats:p>

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