Zusammenfassung:
<jats:title>Abstract</jats:title><jats:p>Here we present a novel strategy for specific cellular targeting of polymeric nanocontainers by using self‐assembly of block copolymers consisting of either Polydimethoxysiloxane‐b‐Polymethyloxazoline‐b‐Polydimethoxysiloxane (PDMS‐b‐PMOXA‐b‐PDMS) or functionalized PDMS‐b‐PMOXA‐b‐PDMS. Covalent functionalization of the above copolymer was accomplished using either the fluorescent dye sulforhodamine B or a poly‐guanosin ligand, the latter by using the Huisgen 1,3‐dipolar cycloaddition. The success of the covalent modification of the block copolymer has been determined by studying functionalized sulforhodamine B by NMR and fluorescence correlation spectroscopy. The covalent click chemistry approach leads to efficiently functionalized polymeric nanocontainers which enables specific uptake by activated macrophages overexpressing the scavenger receptor A1.</jats:p>
Beschreibung:
<jats:title>Abstract</jats:title><jats:p>Here we present a novel strategy for specific cellular targeting of polymeric nanocontainers by using self‐assembly of block copolymers consisting of either Polydimethoxysiloxane‐b‐Polymethyloxazoline‐b‐Polydimethoxysiloxane (PDMS‐b‐PMOXA‐b‐PDMS) or functionalized PDMS‐b‐PMOXA‐b‐PDMS. Covalent functionalization of the above copolymer was accomplished using either the fluorescent dye sulforhodamine B or a poly‐guanosin ligand, the latter by using the Huisgen 1,3‐dipolar cycloaddition. The success of the covalent modification of the block copolymer has been determined by studying functionalized sulforhodamine B by NMR and fluorescence correlation spectroscopy. The covalent click chemistry approach leads to efficiently functionalized polymeric nanocontainers which enables specific uptake by activated macrophages overexpressing the scavenger receptor A1.</jats:p>