• Medientyp: E-Artikel
  • Titel: Towards Targeted Drug Delivery by Covalent Ligand‐Modified Polymeric Nanocontainers
  • Beteiligte: Egli, Stefan; Fischer, Barbara; Hartmann, Sonja; Hunziker, Patrick; Meier, Wolfgang; Rigler, Per
  • Erschienen: Wiley, 2010
  • Erschienen in: Macromolecular Symposia
  • Umfang: 278-285
  • Sprache: Englisch
  • DOI: 10.1002/masy.201051039
  • ISSN: 1022-1360; 1521-3900
  • Schlagwörter: Materials Chemistry ; Polymers and Plastics ; Organic Chemistry ; Condensed Matter Physics
  • Zusammenfassung: <jats:title>Abstract</jats:title><jats:p>Here we present a novel strategy for specific cellular targeting of polymeric nanocontainers by using self‐assembly of block copolymers consisting of either Polydimethoxysiloxane‐b‐Polymethyloxazoline‐b‐Polydimethoxysiloxane (PDMS‐b‐PMOXA‐b‐PDMS) or functionalized PDMS‐b‐PMOXA‐b‐PDMS. Covalent functionalization of the above copolymer was accomplished using either the fluorescent dye sulforhodamine B or a poly‐guanosin ligand, the latter by using the Huisgen 1,3‐dipolar cycloaddition. The success of the covalent modification of the block copolymer has been determined by studying functionalized sulforhodamine B by NMR and fluorescence correlation spectroscopy. The covalent click chemistry approach leads to efficiently functionalized polymeric nanocontainers which enables specific uptake by activated macrophages overexpressing the scavenger receptor A1.</jats:p>
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>Here we present a novel strategy for specific cellular targeting of polymeric nanocontainers by using self‐assembly of block copolymers consisting of either Polydimethoxysiloxane‐b‐Polymethyloxazoline‐b‐Polydimethoxysiloxane (PDMS‐b‐PMOXA‐b‐PDMS) or functionalized PDMS‐b‐PMOXA‐b‐PDMS. Covalent functionalization of the above copolymer was accomplished using either the fluorescent dye sulforhodamine B or a poly‐guanosin ligand, the latter by using the Huisgen 1,3‐dipolar cycloaddition. The success of the covalent modification of the block copolymer has been determined by studying functionalized sulforhodamine B by NMR and fluorescence correlation spectroscopy. The covalent click chemistry approach leads to efficiently functionalized polymeric nanocontainers which enables specific uptake by activated macrophages overexpressing the scavenger receptor A1.</jats:p>
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