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Youssef, Aly; Righetti, Francesca; Morano, Danila; Rizzo, Nicola; Farina, Antonio

Uterine artery Doppler and biochemical markers (PAPP‐A, PlGF, sFlt‐1, P‐selectin, NGAL) at 11 + 0 to 13 + 6 weeks in the prediction of late (34 weeks) pre‐eclampsia

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  • Medientyp: E-Artikel
  • Titel: Uterine artery Doppler and biochemical markers (PAPP‐A, PlGF, sFlt‐1, P‐selectin, NGAL) at 11 + 0 to 13 + 6 weeks in the prediction of late (34 weeks) pre‐eclampsia
  • Beteiligte: Youssef, Aly; Righetti, Francesca; Morano, Danila; Rizzo, Nicola; Farina, Antonio
  • Erschienen: Wiley, 2011
  • Erschienen in: Prenatal Diagnosis
  • Sprache: Englisch
  • DOI: 10.1002/pd.2848
  • ISSN: 0197-3851; 1097-0223
  • Schlagwörter: Genetics (clinical) ; Obstetrics and Gynecology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:sec><jats:title>Objective</jats:title><jats:p>To determine the performance of screening for late pre‐eclampsia (PE) by maternal characteristics, uterine artery Doppler and a set of biochemical markers at 11 + 0 to 13 + 6 weeks' gestation.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Prospectively enrolled women at 11 + 0 to 13 + 6 weeks. Maternal characteristics, highest UtA pulsatility index and serum placental biomarkers including pregnancy‐associated plasma protein‐A, placental growth factor, soluble fms‐like tyrosine kinase 1, P‐selectin and neutrophil gelatinase‐associated lipocalin were recorded.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The rate of PE was 2.5% (13/528). Four (0.8%) had severe PE. A combined screening model that included placental growth factor, soluble fms‐like tyrosine kinase 1 and neutrophil gelatinase‐associated lipocalin could detect 77% of PE at a 10% false‐positive rate. Mean risk for mild PE was 8.8% ± 6.4, mean risk for severe PE was 38.6% ± 4.3. Mean risk for controls was 2% ± 4.1.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>This combination of maternal biochemical variables in the first trimester can detect a consistent number of late PE. Further studies on a new and independent series of data could confirm the presented results. Copyright © 2011 John Wiley &amp; Sons, Ltd.</jats:p></jats:sec>