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Medientyp: E-Artikel Titel: Antifungal constituents of Melicope borbonica Beteiligte: Simonsen, Henrik Toft; Adsersen, Anne; Bremner, Paul; Heinrich, Michael; Wagner Smitt, Ulla; Jaroszewski, Jerzy W. Erschienen: Wiley, 2004 Erschienen in: Phytotherapy Research Umfang: 542-545 Sprache: Englisch DOI: 10.1002/ptr.1482 ISSN: 1099-1573; 0951-418X Schlagwörter: Pharmacology Zusammenfassung: <jats:title>Abstract</jats:title><jats:p>Fractionation of extracts of the leaves of <jats:italic>Melicope borbonica</jats:italic> (syn. <jats:italic>Euodia borbonica</jats:italic> var. <jats:italic>borbonica</jats:italic>), a medicinal plant from the Réunion Island that is traditionally used for wound healing and other ailments, afforded an acetophenone (xanthoxylin) and two coumarins, scoparone and limettin, as the major constituents. All three compounds exhibited moderate antifungal activity against <jats:italic>Candida albicans</jats:italic> and <jats:italic>Penicillium expansum</jats:italic>, in accordance with the traditional use of the plant. Moreover, 2,4,6‐trimethoxyacetophenone (methylxanthoxylin), three other coumarins [7‐(3‐methyl‐2‐butenyloxy)‐6‐methoxycoumarin, cedrelopsin and psoralen], two sesquiterpenes (<jats:italic>α</jats:italic>‐curcumene and 3,6‐epidioxy‐1,10‐bisaboladiene), eugenol, methyleugenol and a lignan (sesamin) were isolated. None of the isolated constituents exhibited antiinflammatory activity <jats:italic>in vitro</jats:italic>. No alkaloids were detected. Copyright © 2004 John Wiley & Sons, Ltd.</jats:p> Beschreibung: <jats:title>Abstract</jats:title><jats:p>Fractionation of extracts of the leaves of <jats:italic>Melicope borbonica</jats:italic> (syn. <jats:italic>Euodia borbonica</jats:italic> var. <jats:italic>borbonica</jats:italic>), a medicinal plant from the Réunion Island that is traditionally used for wound healing and other ailments, afforded an acetophenone (xanthoxylin) and two coumarins, scoparone and limettin, as the major constituents. All three compounds exhibited moderate antifungal activity against <jats:italic>Candida albicans</jats:italic> and <jats:italic>Penicillium expansum</jats:italic>, in accordance with the traditional use of the plant. Moreover, 2,4,6‐trimethoxyacetophenone (methylxanthoxylin), three other coumarins [7‐(3‐methyl‐2‐butenyloxy)‐6‐methoxycoumarin, cedrelopsin and psoralen], two sesquiterpenes (<jats:italic>α</jats:italic>‐curcumene and 3,6‐epidioxy‐1,10‐bisaboladiene), eugenol, methyleugenol and a lignan (sesamin) were isolated. None of the isolated constituents exhibited antiinflammatory activity <jats:italic>in vitro</jats:italic>. No alkaloids were detected. Copyright © 2004 John Wiley & Sons, Ltd.</jats:p> Anmerkungen: