• Medientyp: E-Artikel
  • Titel: An Obesity-RelatedFTOVariant and the Risk of Preeclampsia in a Finnish Study Population
  • Beteiligte: Klemetti, Miira; Hiltunen, Leena M.; Heino, Sanna; Heinonen, Seppo; Kajantie, Eero; Laivuori, Hannele
  • Erschienen: Hindawi Limited, 2011
  • Erschienen in: Journal of Pregnancy
  • Umfang: 1-7
  • Sprache: Englisch
  • DOI: 10.1155/2011/251470
  • ISSN: 2090-2727; 2090-2735
  • Schlagwörter: Obstetrics and Gynecology
  • Zusammenfassung: <jats:p>Previous studies have demonstrated a common variant of the obesity and fat mass-related<jats:italic>FTO</jats:italic>gene, rs9939609, to be associated with obesity, type 2 diabetes, and elevated blood pressure. We investigated whether the<jats:italic>FTO</jats:italic>SNP rs9939609 is associated with the risk of preeclampsia (PE) in a Finnish study population. 485 women with prior PE and 449 women who had given birth after a normotensive pregnancy were genotyped (TaqMan) for the SNP rs9939609. The prevalences of genotypes AA, AT, and TT were 15%, 53%, and 32%, respectively, among the PE cases, and 16%, 47%, and 37%, respectively, among the controls (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.199</mml:mn></mml:math>). We found no evidence of an association between the<jats:italic>FTO</jats:italic>SNP rs9939609 and PE. However, our cases were dominated by severe, early-onset PE. Thus, we are unable to exclude an association with the milder, later-onset form of the disease in which the role of maternal metabolic predisposition could be more significant.</jats:p><jats:p><jats:ext-link ext-link-type="Erratum" /><jats:bold>Erratum to “An Obesity-Related<jats:italic>FTO</jats:italic>Variant and the Risk of Preeclampsia in a Finnish Study Population”</jats:bold><jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="dx.doi.org/10.1155/2012/540682" /></jats:p>
  • Beschreibung: <jats:p>Previous studies have demonstrated a common variant of the obesity and fat mass-related<jats:italic>FTO</jats:italic>gene, rs9939609, to be associated with obesity, type 2 diabetes, and elevated blood pressure. We investigated whether the<jats:italic>FTO</jats:italic>SNP rs9939609 is associated with the risk of preeclampsia (PE) in a Finnish study population. 485 women with prior PE and 449 women who had given birth after a normotensive pregnancy were genotyped (TaqMan) for the SNP rs9939609. The prevalences of genotypes AA, AT, and TT were 15%, 53%, and 32%, respectively, among the PE cases, and 16%, 47%, and 37%, respectively, among the controls (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.199</mml:mn></mml:math>). We found no evidence of an association between the<jats:italic>FTO</jats:italic>SNP rs9939609 and PE. However, our cases were dominated by severe, early-onset PE. Thus, we are unable to exclude an association with the milder, later-onset form of the disease in which the role of maternal metabolic predisposition could be more significant.</jats:p><jats:p><jats:ext-link ext-link-type="Erratum" /><jats:bold>Erratum to “An Obesity-Related<jats:italic>FTO</jats:italic>Variant and the Risk of Preeclampsia in a Finnish Study Population”</jats:bold><jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="dx.doi.org/10.1155/2012/540682" /></jats:p>
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