Karpel, H. Charli;
Ali, Nicole M.;
Lawson, Nikki;
Tatapudi, Vasishta S.;
Friedlander, Rex;
Philogene, Mary Carmelle;
Montgomery, Robert A.;
Lonze, Bonnie E.
Successful A2 to B Deceased Donor Kidney Transplant after Desensitization for High-Strength Non-HLA Antibody Made Possible by Utilizing a Hepatitis C Positive Donor
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Medientyp:
E-Artikel
Titel:
Successful A2 to B Deceased Donor Kidney Transplant after Desensitization for High-Strength Non-HLA Antibody Made Possible by Utilizing a Hepatitis C Positive Donor
Beteiligte:
Karpel, H. Charli;
Ali, Nicole M.;
Lawson, Nikki;
Tatapudi, Vasishta S.;
Friedlander, Rex;
Philogene, Mary Carmelle;
Montgomery, Robert A.;
Lonze, Bonnie E.
Beschreibung:
<jats:p>Desensitization using plasma exchange can remove harmful antibodies prior to transplantation and mitigate risks for hyperacute and severe early acute antibody-mediated rejection. Traditionally, the use of plasma exchange requires a living donor so that the timing of treatments relative to transplant can be planned. Non-HLA antibody is increasingly recognized as capable of causing antibody-mediated renal allograft rejection and has been associated with decreased graft longevity. Our patient had high-strength non-HLA antibody deemed prohibitive to transplantation without desensitization, but no living donors. As the patient was eligible to receive an A2 ABO blood group organ and was willing to accept a hepatitis C positive donor kidney, this afforded a high probability of receiving an offer within a short enough time frame to attempt empiric desensitization in anticipation of a deceased donor transplant. Fifteen plasma exchange treatments were performed before the patient received an organ offer, and the patient was successfully transplanted. Hepatitis C infection was treated posttransplant. No episodes of rejection were observed. At one-year posttransplant, the patient maintains good graft function. In this case, willingness to consider nontraditional donor organs enabled us to mimic living donor desensitization using a deceased donor.</jats:p>