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Garavello, Werner;
Negri, Eva;
Talamini, Renato;
Levi, Fabio;
Zambon, Paola;
Dal Maso, Luigino;
Bosetti, Cristina;
Franceschi, Silvia;
La Vecchia, Carlo
Family History of Cancer, Its Combination with Smoking and Drinking, and Risk of Squamous Cell Carcinoma of the Esophagus
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- Medientyp: E-Artikel
- Titel: Family History of Cancer, Its Combination with Smoking and Drinking, and Risk of Squamous Cell Carcinoma of the Esophagus
- Beteiligte: Garavello, Werner; Negri, Eva; Talamini, Renato; Levi, Fabio; Zambon, Paola; Dal Maso, Luigino; Bosetti, Cristina; Franceschi, Silvia; La Vecchia, Carlo
- Erschienen: American Association for Cancer Research (AACR), 2005
- Erschienen in: Cancer Epidemiology, Biomarkers & Prevention
- Umfang: 1390-1393
- Sprache: Englisch
- DOI: 10.1158/1055-9965.epi-04-0911
- ISSN: 1055-9965; 1538-7755
- Schlagwörter: Oncology ; Epidemiology
- Zusammenfassung: <jats:title>Abstract</jats:title> <jats:p>We analyzed the association between history of cancer in first-degree relatives and the risk of squamous cell carcinoma of the esophagus (SCCE) using data from three case-control studies conducted in Italy and Switzerland on 805 incident, histologically confirmed SCCE, and 3,461 hospital controls. The alcohol- and tobacco-adjusted odds ratio (OR) for a family history of esophageal cancer was 3.2 [95% confidence interval (CI), 1.7-6.2], and the OR was higher when the affected relative was a brother or was diagnosed at age &lt;55 years. Compared to subjects without family history of esophageal cancer, noncurrent smokers, drinking &lt;49 drinks per week, the OR was 2.9 (95% CI, 1.1-7.5) for family history alone, 15.5 (95% CI, 11.7-20.5) for current smokers drinking ≥49 drinks per week without family history of esophageal cancer, and 107.0 (95% CI, 13.0-880.2) for current smokers drinking ≥49 drinks per week who also had a family history of esophageal cancer. The risk of SCCE was also increased in subjects with a family history of cancer of the oral cavity/pharynx (OR, 3.7; 95% CI, 1.5-9.0) and stomach (OR, 2.0; 95% CI, 1.1-3.6), but not of other cancers, nor for a family history of any cancer (OR, 1.0; 95% CI, 0.8-1.4). These data show that, as for many other epithelial cancers, the risk of SCCE is increased in subjects with a family history of the disease, and that—in Western countries—avoidance of alcohol and tobacco is also the best way to prevent SCCE in subjects with a family history of the disease.</jats:p>
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Beschreibung:
<jats:title>Abstract</jats:title>
<jats:p>We analyzed the association between history of cancer in first-degree relatives and the risk of squamous cell carcinoma of the esophagus (SCCE) using data from three case-control studies conducted in Italy and Switzerland on 805 incident, histologically confirmed SCCE, and 3,461 hospital controls. The alcohol- and tobacco-adjusted odds ratio (OR) for a family history of esophageal cancer was 3.2 [95% confidence interval (CI), 1.7-6.2], and the OR was higher when the affected relative was a brother or was diagnosed at age &lt;55 years. Compared to subjects without family history of esophageal cancer, noncurrent smokers, drinking &lt;49 drinks per week, the OR was 2.9 (95% CI, 1.1-7.5) for family history alone, 15.5 (95% CI, 11.7-20.5) for current smokers drinking ≥49 drinks per week without family history of esophageal cancer, and 107.0 (95% CI, 13.0-880.2) for current smokers drinking ≥49 drinks per week who also had a family history of esophageal cancer. The risk of SCCE was also increased in subjects with a family history of cancer of the oral cavity/pharynx (OR, 3.7; 95% CI, 1.5-9.0) and stomach (OR, 2.0; 95% CI, 1.1-3.6), but not of other cancers, nor for a family history of any cancer (OR, 1.0; 95% CI, 0.8-1.4). These data show that, as for many other epithelial cancers, the risk of SCCE is increased in subjects with a family history of the disease, and that—in Western countries—avoidance of alcohol and tobacco is also the best way to prevent SCCE in subjects with a family history of the disease.</jats:p> - Anmerkungen:
- Zugangsstatus: Freier Zugang