• Medientyp: E-Artikel
  • Titel: First Clinical Experience With the DeBakey VAD Continuous-Axial-Flow Pump for Bridge to Transplantation
  • Beteiligte: Wieselthaler, Georg M.; Schima, Heinrich; Hiesmayr, Michael; Pacher, Richard; Laufer, Günther; Noon, George P.; DeBakey, Michael; Wolner, Ernst
  • Erschienen: Ovid Technologies (Wolters Kluwer Health), 2000
  • Erschienen in: Circulation
  • Umfang: 356-359
  • Sprache: Englisch
  • DOI: 10.1161/01.cir.101.4.356
  • ISSN: 0009-7322; 1524-4539
  • Schlagwörter: Physiology (medical) ; Cardiology and Cardiovascular Medicine
  • Zusammenfassung: <jats:p> <jats:italic>Background</jats:italic> —A shortage of donor organs and increased numbers of deaths of patients on the waiting list for cardiac transplantation make mechanical circulatory support for a bridge to transplantation a standard clinical procedure. Continuous-flow rotary blood pumps offer exciting new perspectives. </jats:p> <jats:p> <jats:italic>Methods and Results</jats:italic> —Two male patients (ages 44 and 65 years) suffering from end-stage left heart failure were implanted with a DeBakey VAD axial-flow pump for use as a bridge to transplant. In the initial postoperative period, the mean pump flow was 3.9±0.5 L/min, which equals a mean cardiac index (CI) of 2.3±0.2 L · min <jats:sup>−1</jats:sup> · m <jats:sup>−2</jats:sup> . In both patients, the early postoperative phase was characterized by a completely nonpulsatile flow profile. However, with the recovery of heart function 8 to 12 days after implantation, increasing pulse pressures became evident, and net flow rose to 4.5±0.6 L/min, causing an increase of mean CI up to 2.7±0.2 L · min <jats:sup>−1</jats:sup> · m <jats:sup>−2</jats:sup> . Patients were mobilized and put through regular physical training. Hemolysis stayed in the physiological range and increased only slightly from 2.1±0.8 mg/dL before surgery to 3.3±1.8 mg/dL 6 weeks after implantation. </jats:p> <jats:p> <jats:italic>Conclusions</jats:italic> —The first clinical implants of the DeBakey VAD axial-flow pump have demonstrated the device to be a promising measure of bridge-to-transplant mechanical support. </jats:p>
  • Beschreibung: <jats:p>
    <jats:italic>Background</jats:italic>
    —A shortage of donor organs and increased numbers of deaths of patients on the waiting list for cardiac transplantation make mechanical circulatory support for a bridge to transplantation a standard clinical procedure. Continuous-flow rotary blood pumps offer exciting new perspectives.
    </jats:p>
    <jats:p>
    <jats:italic>Methods and Results</jats:italic>
    —Two male patients (ages 44 and 65 years) suffering from end-stage left heart failure were implanted with a DeBakey VAD axial-flow pump for use as a bridge to transplant. In the initial postoperative period, the mean pump flow was 3.9±0.5 L/min, which equals a mean cardiac index (CI) of 2.3±0.2 L · min
    <jats:sup>−1</jats:sup>
    · m
    <jats:sup>−2</jats:sup>
    . In both patients, the early postoperative phase was characterized by a completely nonpulsatile flow profile. However, with the recovery of heart function 8 to 12 days after implantation, increasing pulse pressures became evident, and net flow rose to 4.5±0.6 L/min, causing an increase of mean CI up to 2.7±0.2 L · min
    <jats:sup>−1</jats:sup>
    · m
    <jats:sup>−2</jats:sup>
    . Patients were mobilized and put through regular physical training. Hemolysis stayed in the physiological range and increased only slightly from 2.1±0.8 mg/dL before surgery to 3.3±1.8 mg/dL 6 weeks after implantation.
    </jats:p>
    <jats:p>
    <jats:italic>Conclusions</jats:italic>
    —The first clinical implants of the DeBakey VAD axial-flow pump have demonstrated the device to be a promising measure of bridge-to-transplant mechanical support.
    </jats:p>
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  • Zugangsstatus: Freier Zugang