Abstract 182: Mimetic peptide overcomes dysregulated L-Type Calcium Channel density and recovers myocardial function

Medientyp: E-Artikel
Titel: Abstract 182: Mimetic peptide overcomes dysregulated L-Type Calcium Channel density and recovers myocardial function
Beteiligte: Rusconi, Francesca; Miragoli, Michele; Di Pasquale, Elisa; Rocchetti, Marcella; Ceriotti, Paola; Carullo, Pierluigi; Caprari, Silvia; Viggiani, Giacomo; Cazade, Magali; Chemin, Jean; Bang, Marie-Louise; Polticelli, Fabio; Zaza, Antonio; Condorelli, Gianluigi; Catalucci, Daniele
Erschienen: Ovid Technologies (Wolters Kluwer Health), 2014
Erschienen in: Circulation Research
Sprache: Englisch
DOI: 10.1161/res.115.suppl_1.182
ISSN: 0009-7330; 1524-4571
Schlagwörter: Cardiology and Cardiovascular Medicine ; Physiology
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Beschreibung: <jats:p> Voltage dependent L-Type calcium-channels (LTCCs) are located on the cardiomyocyte membrane and regulate cardiac contraction and rhythmicity. In human pathologies, such as heart failure (HF), decreased inward calcium current (I <jats:sub>Ca</jats:sub> ) is frequently observed. Here, we generated a mimetic peptide (MP) that targets LTCCs and restores impaired intracellular calcium homeostasis through a novel mechanism. Effective delivery of MP, fused with a cell penetrating peptide, was found to correct Ca2+ alterations in a mouse model of HF, in human cardiomyocytes derived from induced pluripotent stem-cells. These data provide a proof-of-concept supporting a therapeutic role for MP to treat human diseases related to LTCC abnormalities. </jats:p> <jats:p>Category: heart failure biology</jats:p>
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