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Rusconi, Francesca;
Miragoli, Michele;
Di Pasquale, Elisa;
Rocchetti, Marcella;
Ceriotti, Paola;
Carullo, Pierluigi;
Caprari, Silvia;
Viggiani, Giacomo;
Cazade, Magali;
Chemin, Jean;
Bang, Marie-Louise;
Polticelli, Fabio;
Zaza, Antonio;
Condorelli, Gianluigi;
Catalucci, Daniele
Abstract 182: Mimetic peptide overcomes dysregulated L-Type Calcium Channel density and recovers myocardial function
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- Medientyp: E-Artikel
- Titel: Abstract 182: Mimetic peptide overcomes dysregulated L-Type Calcium Channel density and recovers myocardial function
- Beteiligte: Rusconi, Francesca; Miragoli, Michele; Di Pasquale, Elisa; Rocchetti, Marcella; Ceriotti, Paola; Carullo, Pierluigi; Caprari, Silvia; Viggiani, Giacomo; Cazade, Magali; Chemin, Jean; Bang, Marie-Louise; Polticelli, Fabio; Zaza, Antonio; Condorelli, Gianluigi; Catalucci, Daniele
- Erschienen in: Circulation Research
- Erschienen: Ovid Technologies (Wolters Kluwer Health), 2014
- Sprache: Englisch
- DOI: 10.1161/res.115.suppl_1.182
- ISSN: 1524-4571; 0009-7330
- Schlagwörter: Cardiology and Cardiovascular Medicine ; Physiology
- Zusammenfassung: <jats:p> Voltage dependent L-Type calcium-channels (LTCCs) are located on the cardiomyocyte membrane and regulate cardiac contraction and rhythmicity. In human pathologies, such as heart failure (HF), decreased inward calcium current (I <jats:sub>Ca</jats:sub> ) is frequently observed. Here, we generated a mimetic peptide (MP) that targets LTCCs and restores impaired intracellular calcium homeostasis through a novel mechanism. Effective delivery of MP, fused with a cell penetrating peptide, was found to correct Ca2+ alterations in a mouse model of HF, in human cardiomyocytes derived from induced pluripotent stem-cells. These data provide a proof-of-concept supporting a therapeutic role for MP to treat human diseases related to LTCC abnormalities. </jats:p> <jats:p>Category: heart failure biology</jats:p>
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Beschreibung:
<jats:p>
Voltage dependent L-Type calcium-channels (LTCCs) are located on the cardiomyocyte membrane and regulate cardiac contraction and rhythmicity. In human pathologies, such as heart failure (HF), decreased inward calcium current (I
<jats:sub>Ca</jats:sub>
) is frequently observed. Here, we generated a mimetic peptide (MP) that targets LTCCs and restores impaired intracellular calcium homeostasis through a novel mechanism. Effective delivery of MP, fused with a cell penetrating peptide, was found to correct Ca2+ alterations in a mouse model of HF, in human cardiomyocytes derived from induced pluripotent stem-cells. These data provide a proof-of-concept supporting a therapeutic role for MP to treat human diseases related to LTCC abnormalities.
</jats:p>
<jats:p>Category: heart failure biology</jats:p> - Anmerkungen:
- Zugangsstatus: Freier Zugang