Lee, Moon Jeong;
Alvarez, Jessica A.;
Smith, Ellen M.;
Killilea, David W.;
Chmiel, James F.;
Joseph, Patricia M.;
Grossmann, Ruth E.;
Gaggar, Amit;
Ziegler, Thomas R.;
Tangpricha, Vin
Changes in Mineral Micronutrient Status During and After Pulmonary Exacerbation in Adults With Cystic Fibrosis
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Medientyp:
E-Artikel
Titel:
Changes in Mineral Micronutrient Status During and After Pulmonary Exacerbation in Adults With Cystic Fibrosis
Beteiligte:
Lee, Moon Jeong;
Alvarez, Jessica A.;
Smith, Ellen M.;
Killilea, David W.;
Chmiel, James F.;
Joseph, Patricia M.;
Grossmann, Ruth E.;
Gaggar, Amit;
Ziegler, Thomas R.;
Tangpricha, Vin
Erschienen:
Wiley, 2015
Erschienen in:
Nutrition in Clinical Practice, 30 (2015) 6, Seite 838-843
Sprache:
Englisch
DOI:
10.1177/0884533615589991
ISSN:
1941-2452;
0884-5336
Entstehung:
Anmerkungen:
Beschreibung:
Background: Patients with cystic fibrosis (CF) may be at risk for micronutrient depletion, particularly during periods of illness and infection. The purpose of this study was to investigate serum micronutrient status over time in adults with CF initially hospitalized with a pulmonary exacerbation. Materials and Methods: This was an ancillary study of a multicenter trial investigating the role of high‐dose vitamin D supplementation in 24 adults with CF (mean age, 29.6 ± 7.3 years). We measured serum concentrations of copper (Cu), iron (Fe), calcium (Ca), magnesium (Mg), potassium (K), and sulfur (S) in subjects at the beginning of a pulmonary exacerbation and again at 3 months. Results: Serum concentrations of Cu, Fe, and Ca were significantly lower at baseline compared with 3 months following the pulmonary exacerbation (Cu: baseline, 1.5 ± 0.6 vs 3 months, 1.6 ± 0.6 µg/mL, P = .027; Fe: 0.8 ± 0.3 vs 1.3 ± 1.1 µg/mL, P = .026; Ca: 9.7 ± 0.8 vs 10.8 ± 2.0 mg/dL, P = .024). Serum concentrations of K, Mg, and S did not change over time (K: baseline, 4.9 ± 0.3 vs 3 months, 5.1 ± 0.5 mEq/L; Mg: 1.8 ± 0.2 vs 2.0 ± 0.3 mg/dL; S: 1288.6 ± 343 vs 1309.9 ± 290 µg/mL; P > .05 for all). Conclusion: Serum concentrations of Cu, Fe, and Ca increased significantly several months following recovery from acute pulmonary exacerbation in adults with CF. This may reflect decreased inflammation, improved food intake, and/or increased absorption following recovery.