• Medientyp: E-Artikel
  • Titel: Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease
  • Beteiligte: Camus, Stéphane M.; De Moraes, João A.; Bonnin, Philippe; Abbyad, Paul; Le Jeune, Sylvain; Lionnet, François; Loufrani, Laurent; Grimaud, Linda; Lambry, Jean-Christophe; Charue, Dominique; Kiger, Laurent; Renard, Jean-Marie; Larroque, Claire; Le Clésiau, Hervé; Tedgui, Alain; Bruneval, Patrick; Barja-Fidalgo, Christina; Alexandrou, Antigoni; Tharaux, Pierre-Louis; Boulanger, Chantal M.; Blanc-Brude, Olivier P.
  • Erschienen: American Society of Hematology, 2015
  • Erschienen in: Blood
  • Sprache: Englisch
  • DOI: 10.1182/blood-2014-07-589283
  • ISSN: 0006-4971; 1528-0020
  • Schlagwörter: Cell Biology ; Hematology ; Immunology ; Biochemistry
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  • Beschreibung: <jats:title>Key Points</jats:title><jats:p>A significant fraction of cell-free heme in plasma is contained in circulating erythrocyte MPs, particularly during hemolysis. Heme-laden MPs can transfer heme to vascular endothelium and mediate oxidative stress, vascular dysfunction, and vasoocclusions.</jats:p>
  • Zugangsstatus: Freier Zugang