• Medientyp: E-Artikel
  • Titel: A novel B-domain O-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models
  • Beteiligte: Stennicke, Henning R.; Kjalke, Marianne; Karpf, Ditte M.; Balling, Kristoffer W.; Johansen, Peter B.; Elm, Torben; Øvlisen, Kristine; Möller, Flemming; Holmberg, Heidi L.; Gudme, Charlotte N.; Persson, Egon; Hilden, Ida; Pelzer, Hermann; Rahbek-Nielsen, Henrik; Jespersgaard, Christina; Bogsnes, Are; Pedersen, Anette A.; Kristensen, Anne K.; Peschke, Bernd; Kappers, Wendy; Rode, Frederik; Thim, Lars; Tranholm, Mikael; Ezban, Mirella; [...]
  • Erschienen: American Society of Hematology, 2013
  • Erschienen in: Blood, 121 (2013) 11, Seite 2108-2116
  • Sprache: Englisch
  • DOI: 10.1182/blood-2012-01-407494
  • ISSN: 0006-4971; 1528-0020
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  • Beschreibung: Key PointsGlycoPEGylated FVIII (N8-GP) demonstrates the same efficacy and prolonged effect in animal models as native FVIII. Circulatory half-life of glycoPEGylated FVIII (N8-GP) is prolonged by approximately twofold in several species.
  • Zugangsstatus: Freier Zugang