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Medientyp:
E-Artikel
Titel:
Melanoma stem cells
Beteiligte:
Roesch, Alexander
Erschienen:
Wiley, 2015
Erschienen in:
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, 13 (2015) 2, Seite 118-124
Sprache:
Deutsch
DOI:
10.1111/ddg.12584
ISSN:
1610-0379;
1610-0387
Entstehung:
Anmerkungen:
Beschreibung:
SummaryThe cancer stem cell concept significantly broadens our understanding of melanoma biology. However, this concept should be regarded as an integral part of a holistic cancer model that also includes the genetic evolution of tumor cells and the variability of cell phenotypes within a dynamic tumor microenvironment. The biologic complexity and methodological difficulties in identifying cancer stem cells and their biomarkers are currently impeding the direct translation of experimental findings into clinical practice. Nevertheless, it is these methodological shortcomings that provide a new perspective on the phenotypic heterogeneity and plasticity of melanoma with important consequences for future therapies. The development of new combination treatment strategies, particularly with regard to overcoming treatment resistance, could significantly benefit from targeted elimination of cell subpopulations with cancer stem cell properties.