Beschreibung:
<jats:sec><jats:title>Aim</jats:title><jats:p>Restrictive lung dysfunction (<jats:styled-content style="fixed-case">RLD</jats:styled-content>; defined as reduced forced vital capacity [<jats:styled-content style="fixed-case">FVC</jats:styled-content>] in the presence of normal forced expiratory volume in 1 s [<jats:styled-content style="fixed-case">FEV</jats:styled-content>1]/<jats:styled-content style="fixed-case">FVC</jats:styled-content> ratio) is highly prevalent in the elderly, and is associated with diabetes, metabolic syndrome (<jats:styled-content style="fixed-case">MetS</jats:styled-content>) and abdominal obesity. The aim of this study was to assess the relative contribution of diabetes, <jats:styled-content style="fixed-case">MetS</jats:styled-content> and abdominal obesity in characterizing <jats:styled-content style="fixed-case">RLD</jats:styled-content> in the elderly.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This was cross‐sectional analysis of 192 consecutive, community‐dwelling persons (mean age 70.8 ± 8 years). The participants were grouped according to the number of <jats:styled-content style="fixed-case">MetS</jats:styled-content> components (i.e. 0, 1, 2, 3 or 4) and the presence of diabetes. According to the Adult Treatment Panel‐<jats:styled-content style="fixed-case">III</jats:styled-content> criteria, participants with three or four components were considered to be affected by <jats:styled-content style="fixed-case">MetS</jats:styled-content>. Independent correlates of <jats:styled-content style="fixed-case">RLD</jats:styled-content> and obstructive lung dysfunction (<jats:styled-content style="fixed-case">OLD</jats:styled-content>; <jats:styled-content style="fixed-case">FEV</jats:styled-content>1/<jats:styled-content style="fixed-case">FVC</jats:styled-content> < 0.70) were assessed by logistic regression models.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The mean age of the sample population was 70.8 years. <jats:styled-content style="fixed-case">FVC</jats:styled-content> expressed as percent of the predicted value declined for an increasing number of <jats:styled-content style="fixed-case">MetS</jats:styled-content> components (<jats:italic>P</jats:italic> < 0.0001), but diabetes did not account for further ventilatory decline. Consistently, <jats:styled-content style="fixed-case">MetS</jats:styled-content> (<jats:styled-content style="fixed-case">OR</jats:styled-content> 3.03, 95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 1.16–7.89) and abdominal obesity (<jats:styled-content style="fixed-case">OR</jats:styled-content> 4.89, 95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 1.17–20.3), but not diabetes, were independently associated with <jats:styled-content style="fixed-case">RLD</jats:styled-content>. <jats:styled-content style="fixed-case">OLD</jats:styled-content> did not worsen for an increasing number of <jats:styled-content style="fixed-case">MetS</jats:styled-content> components and was only related to age (<jats:styled-content style="fixed-case">OR</jats:styled-content> 1.07, 95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 1.01–1.13) and smoking (<jats:styled-content style="fixed-case">OR</jats:styled-content> 1.04, 95% <jats:styled-content style="fixed-case">CI</jats:styled-content> 1.01–1.06).</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p><jats:styled-content style="fixed-case">MetS</jats:styled-content> and abdominal obesity, two conditions of prediabetes, but not diabetes itself, are closely associated with <jats:styled-content style="fixed-case">RLD</jats:styled-content>. These conditions might be implicated in the pathogenesis of the <jats:styled-content style="fixed-case">RLD</jats:styled-content>, which is frequently observed in diabetic patients. <jats:bold>Geriatr Gerontol Int 2013; 13: 894–900.</jats:bold></jats:p></jats:sec>