• Medientyp: E-Artikel
  • Titel: Prognostic factors in the surgical treatment of patients with oral carcinoma
  • Beteiligte: Patel, Rajan S.; Clark, Jonathan R.; Dirven, Richard; Wyten, Rebecca; Gao, Kan; O’Brien, Christopher J.
  • Erschienen: Wiley, 2009
  • Erschienen in: ANZ Journal of Surgery
  • Sprache: Englisch
  • DOI: 10.1111/j.1445-2197.2008.04791.x
  • ISSN: 1445-2197; 1445-1433
  • Schlagwörter: General Medicine ; Surgery
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Abstract</jats:title><jats:p>The aim of the study was to analyse the clinical outcome of patients treated surgically for oral carcinoma. A retrospective cohort study was undertaken of 356 patients with oral cavity cancer whose clinicopathological information had been collected prospectively onto a dedicated head and neck database. Disease recurrence and survival were assessed. Neck metastases occurred in 42% of patients. Tumour thickness (both 2 and 5 mm) predicted the presence of nodal metastases. Both pathological T stage (<jats:italic>P</jats:italic> &lt; 0.001) and tumour thickness cut‐off of 5 mm (<jats:italic>P</jats:italic> = 0.03) were independent predictors of disease‐specific survival. With a median follow up of 41 months, overall survival at 5 years was 59% and disease‐specific survival was 73%. Patients with thick tumours have a high risk of nodal metastases and this supports the liberal use of elective selective neck dissection in patients with clinically negative necks.</jats:p>