• Medientyp: E-Artikel
  • Titel: High sensitivity of quick view capsule endoscopy for detection of small bowel Crohn's disease
  • Beteiligte: Halling, Morten Lee; Nathan, Torben; Kjeldsen, Jens; Jensen, Michael Dam
  • Erschienen: Wiley, 2014
  • Erschienen in: Journal of Gastroenterology and Hepatology
  • Umfang: 992-996
  • Sprache: Englisch
  • DOI: 10.1111/jgh.12488
  • ISSN: 0815-9319; 1440-1746
  • Schlagwörter: Gastroenterology ; Hepatology
  • Zusammenfassung: <jats:title>Abstract</jats:title><jats:sec><jats:title>Background and Aim</jats:title><jats:p>Capsule endoscopy (<jats:styled-content style="fixed-case">CE</jats:styled-content>) has a high sensitivity for diagnosing small bowel <jats:styled-content style="fixed-case">C</jats:styled-content>rohn's disease, but video analysis is time‐consuming. The quick view (qv) function is an effective tool to reduce time consumption. The aim of this study was to determine the rate of missed small bowel ulcerations with qv‐<jats:styled-content style="fixed-case">CE</jats:styled-content> compared with standard view and the diagnostic accuracy of qv‐<jats:styled-content style="fixed-case">CE</jats:styled-content> in suspected <jats:styled-content style="fixed-case">C</jats:styled-content>rohn's disease.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This study consisted of two parts: (i) 12 small bowel segments with <jats:styled-content style="fixed-case">C</jats:styled-content>rohn's disease of varying severity were selected for a detailed analysis of the number and type of lesions visualized with <jats:styled-content style="fixed-case">CE</jats:styled-content> and qv‐<jats:styled-content style="fixed-case">CE</jats:styled-content>, and (ii) a blinded study of the diagnostic accuracy of qv‐<jats:styled-content style="fixed-case">CE</jats:styled-content> including 40 patients with suspected <jats:styled-content style="fixed-case">C</jats:styled-content>rohn's disease. Ileocolonoscopy and <jats:styled-content style="fixed-case">CE</jats:styled-content> served as gold standard.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Part 1: <jats:styled-content style="fixed-case">CE</jats:styled-content> visualized 171 ulcerations compared with 102 detected with qv‐<jats:styled-content style="fixed-case">CE</jats:styled-content> (miss rate 40%, <jats:italic>P</jats:italic> = 0.02). Part 2: qv‐<jats:styled-content style="fixed-case">CE</jats:styled-content> identified 15 of 16 patients with small bowel <jats:styled-content style="fixed-case">C</jats:styled-content>rohn's disease corresponding to a 94% sensitivity, and overall, 39 out of 40 patients were classified correct (diagnostic accuracy 98%). Qv‐<jats:styled-content style="fixed-case">CE</jats:styled-content> was false negative in one patient because of a leap of 3 min and 20 s in the terminal ileum. Reading times varied from 5 to 18 min (median 10).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Despite a significant number of missed lesions, qv‐<jats:styled-content style="fixed-case">CE</jats:styled-content> is a safe and time‐reducing method for diagnosing small bowel <jats:styled-content style="fixed-case">C</jats:styled-content>rohn's disease. To avoid false negative cases, we recommend viewing the terminal ileum in standard view.</jats:p></jats:sec>
  • Beschreibung: <jats:title>Abstract</jats:title><jats:sec><jats:title>Background and Aim</jats:title><jats:p>Capsule endoscopy (<jats:styled-content style="fixed-case">CE</jats:styled-content>) has a high sensitivity for diagnosing small bowel <jats:styled-content style="fixed-case">C</jats:styled-content>rohn's disease, but video analysis is time‐consuming. The quick view (qv) function is an effective tool to reduce time consumption. The aim of this study was to determine the rate of missed small bowel ulcerations with qv‐<jats:styled-content style="fixed-case">CE</jats:styled-content> compared with standard view and the diagnostic accuracy of qv‐<jats:styled-content style="fixed-case">CE</jats:styled-content> in suspected <jats:styled-content style="fixed-case">C</jats:styled-content>rohn's disease.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>This study consisted of two parts: (i) 12 small bowel segments with <jats:styled-content style="fixed-case">C</jats:styled-content>rohn's disease of varying severity were selected for a detailed analysis of the number and type of lesions visualized with <jats:styled-content style="fixed-case">CE</jats:styled-content> and qv‐<jats:styled-content style="fixed-case">CE</jats:styled-content>, and (ii) a blinded study of the diagnostic accuracy of qv‐<jats:styled-content style="fixed-case">CE</jats:styled-content> including 40 patients with suspected <jats:styled-content style="fixed-case">C</jats:styled-content>rohn's disease. Ileocolonoscopy and <jats:styled-content style="fixed-case">CE</jats:styled-content> served as gold standard.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Part 1: <jats:styled-content style="fixed-case">CE</jats:styled-content> visualized 171 ulcerations compared with 102 detected with qv‐<jats:styled-content style="fixed-case">CE</jats:styled-content> (miss rate 40%, <jats:italic>P</jats:italic> = 0.02). Part 2: qv‐<jats:styled-content style="fixed-case">CE</jats:styled-content> identified 15 of 16 patients with small bowel <jats:styled-content style="fixed-case">C</jats:styled-content>rohn's disease corresponding to a 94% sensitivity, and overall, 39 out of 40 patients were classified correct (diagnostic accuracy 98%). Qv‐<jats:styled-content style="fixed-case">CE</jats:styled-content> was false negative in one patient because of a leap of 3 min and 20 s in the terminal ileum. Reading times varied from 5 to 18 min (median 10).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Despite a significant number of missed lesions, qv‐<jats:styled-content style="fixed-case">CE</jats:styled-content> is a safe and time‐reducing method for diagnosing small bowel <jats:styled-content style="fixed-case">C</jats:styled-content>rohn's disease. To avoid false negative cases, we recommend viewing the terminal ileum in standard view.</jats:p></jats:sec>
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