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Kuzmin, Elena; VanderSluis, Benjamin; Wang, Wen; Tan, Guihong; Deshpande, Raamesh; Chen, Yiqun; Usaj, Matej; Balint, Attila; Mattiazzi Usaj, Mojca; van Leeuwen, Jolanda; Koch, Elizabeth N.; Pons, Carles; Dagilis, Andrius J.; Pryszlak, Michael; Wang, Jason Zi Yang; Hanchard, Julia; Riggi, Margot; Xu, Kaicong; Heydari, Hamed; San Luis, Bryan-Joseph; Shuteriqi, Ermira; Zhu, Hongwei; Van Dyk, Nydia; Sharifpoor, Sara; [...]

Systematic analysis of complex genetic interactions

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  • Medientyp: E-Artikel
  • Titel: Systematic analysis of complex genetic interactions
  • Beteiligte: Kuzmin, Elena; VanderSluis, Benjamin; Wang, Wen; Tan, Guihong; Deshpande, Raamesh; Chen, Yiqun; Usaj, Matej; Balint, Attila; Mattiazzi Usaj, Mojca; van Leeuwen, Jolanda; Koch, Elizabeth N.; Pons, Carles; Dagilis, Andrius J.; Pryszlak, Michael; Wang, Jason Zi Yang; Hanchard, Julia; Riggi, Margot; Xu, Kaicong; Heydari, Hamed; San Luis, Bryan-Joseph; Shuteriqi, Ermira; Zhu, Hongwei; Van Dyk, Nydia; Sharifpoor, Sara; [...]
  • Erschienen: American Association for the Advancement of Science (AAAS), 2018
  • Erschienen in: Science
  • Sprache: Englisch
  • DOI: 10.1126/science.aao1729
  • ISSN: 1095-9203; 0036-8075
  • Schlagwörter: Multidisciplinary
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: <jats:title>Trigenic interactions in yeast link bioprocesses</jats:title> <jats:p> To dissect the genotype-phenotype landscape of a cell, it is necessary to understand interactions between genes. Building on the digenic protein-protein interaction network, Kuzmin <jats:italic>et al.</jats:italic> created a trigenic landscape of yeast by using a synthetic genetic array (see the Perspective by Walhout). Triple-mutant analyses indicated that the majority of genes with trigenic associations functioned within the same biological processes. These converged on networks identified in the digenic interaction landscape. Although the overall effects were weaker for trigenic than for digenic interactions, trigenic interactions were more likely to bridge biological processes in the cell. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aao1729">eaao1729</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6386" page="269" related-article-type="in-this-issue" vol="360" xlink:href="10.1126/science.aat4667">269</jats:related-article> </jats:p>