High Seroprevalence of Herpes Simplex Virus Type 2 Infection in French Human Immunodeficiency Virus … - SLUB Dresden

Medientyp: E-Artikel

Titel: High Seroprevalence of Herpes Simplex Virus Type 2 Infection in French Human Immunodeficiency Virus Type 1-Infected Outpatients

Beteiligte: Andréoletti, Laurent ; Piednoir, Emmanuel ; Legoff, Jérôme ; Brodard, Véronique ; Beguinot, Isabelle ; Strady, Christophe ; Rouger, Christine ; Piketty, Christophe ; Si-Mohamed, Ali ; Kazatchkine, Michel Daniel ; Malkin, Jean-Elie ; Bélec, Laurent

Erschienen: American Society for Microbiology, 2005

Sprache: Englisch

DOI: 10.1128/jcm.43.8.4215-4217.2005

ISSN: 1098-660X; 0095-1137

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Beschreibung: ABSTRACT Using commercially available herpes simplex virus (HSV) type-specific serological diagnostic tests, HSV type 2 (HSV-2) antibody prevalence was assessed in two parallel prospective studies including 534 human immunodeficiency virus type 1 (HIV-1)-infected outpatients living in two areas of northern France. In the first cohort of 434 subjects, 223 (51%) individuals demonstrated a positive HSV-2 serological status while 66 (66%) of 100 subjects in the second cohort were seropositive for HSV-2 (51 versus 66%; P = 0.08). Among the 223 HSV-2-seropositive subjects identified in the first study cohort, only 22 (10%) had suffered from recurrent anogenital lesions during the past 12 months while 154 (69%) had no clinical history of herpesvirus infection. Our findings demonstrate high proportions of subclinical and undiagnosed HSV-2 infection in HIV-1-infected individuals and suggest that HSV type-specific serological testing in the French HIV-1-infected subpopulation could be an efficient strategy to diagnose clinically asymptomatic HSV-2 infections.

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