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Medientyp:
E-Artikel
Titel:
Deletion of Herpes Simplex Virus 1 MicroRNAs miR-H1 and miR-H6 Impairs Reactivation
Beteiligte:
Barrozo, Enrico R.;
Nakayama, Sanae;
Singh, Pankaj;
Vanni, Emilia A. H.;
Arvin, Ann M.;
Neumann, Donna M.;
Bloom, David C.
Erschienen:
American Society for Microbiology, 2020
Erschienen in:
Journal of Virology, 94 (2020) 15
Sprache:
Englisch
DOI:
10.1128/jvi.00639-20
ISSN:
0022-538X;
1098-5514
Entstehung:
Anmerkungen:
Beschreibung:
While HSV antivirals reduce the severity and duration of clinical disease in some individuals, there is no vaccine or cure. Therefore, understanding the mechanisms regulating latency and reactivation as a potential to elucidate targets for better therapeutics is important. There are at least 20 confirmed HSV-1 miRNAs, yet the roles of individual miRNAs in the context of viral infection remain largely uncharacterized. The present study focuses on two of the miRNAs (miR-H1/H6) that are encoded within the latency-associated transcript (LAT) region, a portion of the genome that has been associated with efficient reactivation. Here, we demonstrate that the deletion of the seed sequences of these miRNAs results in a severe reduction in reactivation of HSV-1 in the mouse and rabbit models. These results suggest a linkage between these miRNAs and reactivation.