• Medientyp: E-Artikel
  • Titel: Real-world crude incidence of hypoglycemia in adults with diabetes: Results of the InHypo-DM Study, Canada
  • Beteiligte: Ratzki-Leewing, Alexandria; Harris, Stewart B; Mequanint, Selam; Reichert, Sonja M; Belle Brown, Judith; Black, Jason Edward; Ryan, Bridget L
  • Quelle: BMJ Open Diabetes Research & Care ; 6 ( 2018 ) S. e000503
  • Erschienen: BMJ, 2018
  • Sprache: Englisch
  • DOI: 10.1136/bmjdrc-2017-000503
  • ISSN: 2052-4897
  • Schlagwörter: Endocrinology, Diabetes and Metabolism
  • Zusammenfassung: <jats:sec><jats:title>Objective</jats:title><jats:p>Very few real-world studies have been conducted to assess the incidence of diabetes-related hypoglycemia. Moreover, there is a paucity of studies that have investigated hypoglycemia among people taking secretagogues as a monotherapy or in combination with insulin. Accordingly, our research team developed and validated the InHypo-DM Person with Diabetes Mellitus Questionnaire (InHypo-DMPQ) with the aim of capturing the real-world incidence of self-reported, symptomatic hypoglycemia. The questionnaire was administered online to a national sample of Canadians (≥18 years old) with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) treated with insulin and/or insulin secretagogues.</jats:p></jats:sec><jats:sec><jats:title>Research design and methods</jats:title><jats:p>Self-report data obtained from the InHypo-DMPQ were descriptively analyzed to ascertain the crude incidence proportions and annualized incidence densities (rates) of 30-day retrospective non-severe and 1-year retrospective severe hypoglycemia, including daytime and nocturnal events.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 552 people (T2DM: 83%; T1DM: 17%) completed the questionnaire. Over half (65.2%) of the total respondents reported experiencing at least one event (non-severe or severe) at an annualized crude incidence density of 35.1 events per person-year. The incidence proportion and rate of non-severe events were higher among people with T1DM versus T2DM (77% and 55.7 events per person-year vs 54% and 28.0 events per person-year). Severe hypoglycemia was reported by 41.8% of all respondents, at an average rate of 2.5 events per person-year.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The results of the InHypo-DMPQ, the largest real-world investigation of hypoglycemia epidemiology in Canada, suggest that the incidence of hypoglycemia among adults with diabetes taking insulin and/or insulin secretagogues is higher than previously thought.</jats:p></jats:sec>
  • Beschreibung: <jats:sec><jats:title>Objective</jats:title><jats:p>Very few real-world studies have been conducted to assess the incidence of diabetes-related hypoglycemia. Moreover, there is a paucity of studies that have investigated hypoglycemia among people taking secretagogues as a monotherapy or in combination with insulin. Accordingly, our research team developed and validated the InHypo-DM Person with Diabetes Mellitus Questionnaire (InHypo-DMPQ) with the aim of capturing the real-world incidence of self-reported, symptomatic hypoglycemia. The questionnaire was administered online to a national sample of Canadians (≥18 years old) with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) treated with insulin and/or insulin secretagogues.</jats:p></jats:sec><jats:sec><jats:title>Research design and methods</jats:title><jats:p>Self-report data obtained from the InHypo-DMPQ were descriptively analyzed to ascertain the crude incidence proportions and annualized incidence densities (rates) of 30-day retrospective non-severe and 1-year retrospective severe hypoglycemia, including daytime and nocturnal events.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>A total of 552 people (T2DM: 83%; T1DM: 17%) completed the questionnaire. Over half (65.2%) of the total respondents reported experiencing at least one event (non-severe or severe) at an annualized crude incidence density of 35.1 events per person-year. The incidence proportion and rate of non-severe events were higher among people with T1DM versus T2DM (77% and 55.7 events per person-year vs 54% and 28.0 events per person-year). Severe hypoglycemia was reported by 41.8% of all respondents, at an average rate of 2.5 events per person-year.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The results of the InHypo-DMPQ, the largest real-world investigation of hypoglycemia epidemiology in Canada, suggest that the incidence of hypoglycemia among adults with diabetes taking insulin and/or insulin secretagogues is higher than previously thought.</jats:p></jats:sec>