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Grech, Allison Marie; Kizirian, Nathalie; Lal, Ravin; Zankl, Angelika; Birkner, Karin; Nasir, Reeja; Muirhead, Roslyn; Sau-Harvey, Rachelle; Haghighi, Marjan Mosalman; Collins, Clare; Holmes, Andrew; Skilton, Michael; Simpson, Stephen; Gordon, Adrienne

Cohort profile: the BABY1000 pilot prospective longitudinal birth cohort study based in Sydney, Australia

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  • Medientyp: E-Artikel
  • Titel: Cohort profile: the BABY1000 pilot prospective longitudinal birth cohort study based in Sydney, Australia
  • Beteiligte: Grech, Allison Marie; Kizirian, Nathalie; Lal, Ravin; Zankl, Angelika; Birkner, Karin; Nasir, Reeja; Muirhead, Roslyn; Sau-Harvey, Rachelle; Haghighi, Marjan Mosalman; Collins, Clare; Holmes, Andrew; Skilton, Michael; Simpson, Stephen; Gordon, Adrienne
  • Erschienen: BMJ, 2023
  • Erschienen in: BMJ Open, 13 (2023) 6, Seite e068275
  • Sprache: Englisch
  • DOI: 10.1136/bmjopen-2022-068275
  • ISSN: 2044-6055
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: PurposeThe health of parents prior to conception, a woman’s health during pregnancy and the infant’s environment across their first months and years collectively have profound effects on the child’s health across the lifespan. Since there are very few cohort studies in early pregnancy, gaps remain in our understanding of the mechanisms underpinning these relationships, and how health may be optimised. ‘BABY1000’, a pilot prospective longitudinal birth cohort study, aims to (1) identify factors before and during pregnancy and early life that impact longer-term health and (2) assess the feasibility and acceptability of study design to inform future research.ParticipantsParticipants were based in Sydney, Australia. Women were recruited at preconception or 12 weeks’ gestation, and data were collected from them throughout pregnancy and postpartum, their children until the age of 2 years, and dietary information from a partner (if able) at the last study visit. The pilot aimed to recruit 250 women. However, recruitment ceased earlier than planned secondary to limitations from the COVID-19 pandemic and the final number of subjects was 225.Findings to dateBiosamples, clinical measurements and sociodemographic/psychosocial measures were collected using validated tools and questionnaires. Data analysis and 24-month follow-up assessments for children are ongoing. Key early findings presented include participant demographics and dietary adequacy during pregnancy. The COVID-19 pandemic and associated public health and research restrictions affected recruitment of participants, follow-up assessments and data completeness.Future plansThe BABY1000 study will provide further insight into the developmental origins of health and disease and inform design and implementation of future cohort and intervention studies in the field. Since the BABY1000 pilot was conducted across the COVID-19 pandemic, it also provides unique insight into the early impacts of the pandemic on families, which may have effects on health across the lifespan.
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