Design of a dedicated circular coil for Magnetic Resonance Spectroscopy studies in small phantoms and animal acquisition with a 3 Tesla Magnetic Resonance clinical scanner
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Medientyp:
E-Artikel
Titel:
Design of a dedicated circular coil for Magnetic Resonance Spectroscopy studies in small phantoms and animal acquisition with a 3 Tesla Magnetic Resonance clinical scanner
Erschienen in:
Polish Journal of Medical Physics and Engineering, 26 (2020) 4, Seite 269-276
Sprache:
Englisch
DOI:
10.2478/pjmpe-2020-0032
ISSN:
1898-0309
Entstehung:
Anmerkungen:
Beschreibung:
<jats:title>Abstract</jats:title>
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<jats:italic>Introduction:</jats:italic> Magnetic Resonance Spectroscopy (MRS) is a very powerful tool to explore the tissue components, by allowing a selective identification of molecules and molecular distribution mapping. Due to intrinsic Signal-to-Noise Ratio limitations (SNR), MRS in small phantoms and animals with a clinical scanner requires the design and development of dedicated radiofrequency (RF) coils, a task of fundamental importance. In this article, the authors describe the simulation, design, and application of a <jats:sup>1</jats:sup>H transmit/receive circular coil suitable for MRS studies in small phantoms and small animal models with a clinical 3T scanner. In particular, the circular coil could be an improvement in animal experiments for tumor studies in which the lesions are localized in specific areas.</jats:p>
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<jats:italic>Material and methods:</jats:italic> The magnetic field pattern was calculated using the Biot–Savart law and the inductance was evaluated with analytical calculations. Finally, the coil sensitivity was measured with the perturbing sphere method. Successively, a prototype of the coil was built and tested on the workbench and by the acquisition of MRS data.</jats:p>
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<jats:italic>Results:</jats:italic> In this work, we demonstrate the design trade-offs for successfully developing a dedicated coil for MRS experiments in small phantoms and animals with a clinical scanner. The coil designed in the study offers the potential for obtaining MRS data with a high SNR and good spectral resolution.</jats:p>
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<jats:italic>Conclusions:</jats:italic> The paper provides details of the design, modelling, and construction of a dedicated circular coil, which represents a low cost and easy to build answer for MRS experiments in small samples with a clinical scanner.</jats:p>