De Santis, Stefania;
Liso, Marina;
Verna, Giulio;
Curci, Francesca;
Milani, Gualtiero;
Faienza, Maria Felicia;
Franchini, Carlo;
Moschetta, Antonio;
Chieppa, Marcello;
Clodoveo, Maria Lisa;
Crupi, Pasquale;
Corbo, Filomena
Extra Virgin Olive Oil Extracts Modulate the Inflammatory Ability of Murine Dendritic Cells Based on Their Polyphenols Pattern: Correlation between Chemical Composition and Biological Function
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Medientyp:
E-Artikel
Titel:
Extra Virgin Olive Oil Extracts Modulate the Inflammatory Ability of Murine Dendritic Cells Based on Their Polyphenols Pattern: Correlation between Chemical Composition and Biological Function
Beteiligte:
De Santis, Stefania;
Liso, Marina;
Verna, Giulio;
Curci, Francesca;
Milani, Gualtiero;
Faienza, Maria Felicia;
Franchini, Carlo;
Moschetta, Antonio;
Chieppa, Marcello;
Clodoveo, Maria Lisa;
Crupi, Pasquale;
Corbo, Filomena
Beschreibung:
<jats:p>Extra virgin olive oil (EVOO) represents one of the most important health-promoting foods whose antioxidant and anti-inflammatory activities are mainly associated to its polyphenols content. To date, studies exploring the effect of EVOO polyphenols on dendritic cells (DCs), acting as a crosstalk between the innate and the adaptive immune response, are scanty. Therefore, we studied the ability of three EVOO extracts (cv. Coratina, Cima di Mola/Coratina, and Casaliva), characterized by different polyphenols amount, to regulate DCs maturation in resting conditions or after an inflammatory stimulus. Cima di Mola/Coratina and Casaliva extracts were demonstrated to be the most effective in modulating DCs toward an anti-inflammatory profile by reduction of TNF and IL-6 secretion and CD86 expression, along with a down-modulation of Il-1β and iNOS expression. From factorial analysis results, 9 polyphenols were tentatively established to play a synergistic role in modulating DCs inflammatory ability, thus reducing the risk of chronic inflammation.</jats:p>