Woolhouse, M. E. J.;
Dye, C.;
Smith, T.;
Charlwood, J. D.;
Garnett, G. P.;
Hagan, P.;
Hii, J. L. K.;
Ndhlovu, P. D.;
Quinnell, R. J.;
Watts, C. H.;
Chandiwana, S. K.;
Anderson, R. M.
Heterogeneities in the Transmission of Infectious Agents: Implications for the Design of Control Programs
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Medientyp:
E-Artikel
Titel:
Heterogeneities in the Transmission of Infectious Agents: Implications for the Design of Control Programs
Beteiligte:
Woolhouse, M. E. J.;
Dye, C.;
Smith, T.;
Charlwood, J. D.;
Garnett, G. P.;
Hagan, P.;
Hii, J. L. K.;
Ndhlovu, P. D.;
Quinnell, R. J.;
Watts, C. H.;
Chandiwana, S. K.;
Anderson, R. M.
Erschienen:
National Academy of Sciences of the United States of America, 1997
Erschienen in:Proceedings of the National Academy of Sciences of the United States of America
Sprache:
Englisch
ISSN:
0027-8424
Entstehung:
Anmerkungen:
Beschreibung:
<p>From an analysis of the distributions of measures of transmission rates among hosts, we identify an empirical relationship suggesting that, typically, 20% of the host population contributes at least 80% of the net transmission potential, as measured by the basic reproduction number, R<sub>0</sub>. This is an example of a statistical pattern known as the 20/80 rule. The rule applies to a variety of disease systems, including vector-borne parasites and sexually transmitted pathogens. The rule implies that control programs targeted at the ``core'' 20% group are potentially highly effective and, conversely, that programs that fail to reach all of this group will be much less effective than expected in reducing levels of infection in the population as a whole.</p>