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Medientyp:
E-Artikel
Titel:
Isolation of a Cationic Polypeptide from Human Serum that Stimulates Proliferation of 3T3 Cells
Beteiligte:
Antoniades, Harry N.;
Stathakos, Dimitri;
Scher, Charles D.
Erschienen:
National Academy of Sciences of the United States of America, 1975
Erschienen in:Proceedings of the National Academy of Sciences of the United States of America
Sprache:
Englisch
ISSN:
0027-8424
Entstehung:
Anmerkungen:
Beschreibung:
<p>A basic polypeptide that stimulates DNA synthesis and cell division in confluent populations of mouse Balb/c-3T3 cells has been isolated from whole human serum, and has been separated from the heterogenous group of molecules with insulin-like activity. This highly purified basic polypeptide has a molecular weight of 1.3 × 10<sup>4</sup>and an isoelectric point of 9.7. Approximately 10<sup>7</sup>polypeptide molecules in the growth medium allow the replication of one density-inhibited cell.</p>