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Medientyp:
E-Artikel
Titel:
Functional CD8⁺ but Not CD4⁺ T Cell Responses Develop Independent of Thymic Epithelial MHC
Beteiligte:
Martinic, Marianne M.;
van den Broek, Maries F.;
Rülicke, Thomas;
Huber, Christoph;
Odermatt, Bernhard;
Reith, Walter;
Horvath, Edit;
Zellweger, Raphael;
Fink, Katja;
Recher, Mike;
Eschli, Bruno;
Hengartner, Hans;
Zinkernagel, Rolf M.
Erschienen:
National Academy of Sciences, 2006
Erschienen in:Proceedings of the National Academy of Sciences of the United States of America
Sprache:
Englisch
ISSN:
0027-8424
Entstehung:
Anmerkungen:
Beschreibung:
<p>The role of nonthymic epithelial (non-TE) MHC in T cell repertoire selection remains controversial. To analyze the relative roles of thymic epithelial (TE) and non-TE MHC in T cell repertoire selection, we have generated tetraparental aggregation chimeras (B6-nude↔BALB/c and B6↔BALB/c-nude) harboring T and B cells from both parents, whereas TE cells originated exclusively from the non-nude donor. These chimeras mounted protective virus-specific TE and non-TE MHC-restricted T cell responses. To further evaluate whether non-TE MHC alone was sufficient to generate a functional T cell repertoire, we generated tetraparental aggregation chimeras lacking MHC class II (<tex-math>$B6-nude\leftrightarrowMHCII^{-/-}$</tex-math>) or both MHC molecules (<tex-math>$B6-nude\leftrightarrowMHCI^{-/-}II^{-/-}$</tex-math>) on TE cells, but not on cells of B6-nude origin. Chimeras with MHC-deficient TE cells mounted functional virus-specific CD8⁺ but not CD4⁺ T cell responses. Thus, maturation of functional CD4⁺ T cell responses required MHC class II on thymic epithelium, whereas CD8⁺ T cells matured in the absence of TE MHC.</p>