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Gonneaud, Julie; Baria, Alex T.; Pichet Binette, Alexa; Gordon, Brian A.; Chhatwal, Jasmeer P.; Cruchaga, Carlos; Jucker, Mathias; Levin, Johannes; Salloway, Stephen; Farlow, Martin; Gauthier, Serge; Benzinger, Tammie L. S.; Morris, John C.; Bateman, Randall J.; Breitner, John C. S.; Poirier, Judes; Vachon-Presseau, Etienne; Villeneuve, Sylvia; Weiner, Michael; Rosen, Howard J.; Miller, Bruce L.; Aisen, Paul; Thomas, Ronald G.; Donohue, Michael; [...]Accelerated functional brain aging in pre-clinical familial Alzheimer’s diseaseView onlineSchließen
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Published in: Nature Communications
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Risacher, Shannon L.; Anderson, Wesley H.; Charil, Arnaud; Castelluccio, Peter F.; Shcherbinin, Sergey; Saykin, Andrew J.; Schwarz, Adam J.; Weiner, Michael W.; Aisen, Paul; Petersen, Ronald; Jack, Clifford R.; Jagust, William; Trojanowki, John Q.; Toga, Arthur W.; Beckett, Laurel; Green, Robert C.; Morris, John; Shaw, Leslie M.; Khachaturian, Zaven; Sorensen, Greg; Carrillo, Maria; Kuller, Lew; Raichle, Marc; Paul, Steven; [...]Alzheimer disease brain atrophy subtypes are associated with cognition and rate of declineView onlineSchließen
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Published in: Neurology
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Zhang, Xiuming; Mormino, Elizabeth C.; Sun, Nanbo; Sperling, Reisa A.; Sabuncu, Mert R.; Yeo, B. T. Thomas; Weiner, Michael W.; Aisen, Paul; Weiner, Michael; Aisen, Paul; Petersen, Ronald; Jack, Clifford R.; Jagust, William; Trojanowki, John Q.; Toga, Arthur W.; Beckett, Laurel; Green, Robert C.; Saykin, Andrew J.; Morris, John; Shaw, Leslie M.; Khachaturian, Zaven; Sorensen, Greg; Carrillo, Maria; Kuller, Lew; [...]Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer’s diseaseView onlineSchließen
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Published in: Proceedings of the National Academy of Sciences
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Yin, Chenzhong; Imms, Phoebe; Cheng, Mingxi; Amgalan, Anar; Chowdhury, Nahian F.; Massett, Roy J.; Chaudhari, Nikhil N.; Chen, Xinghe; Thompson, Paul M.; Bogdan, Paul; Irimia, Andrei; Weiner, Michael W.; Aisen, Paul; Petersen, Ronald; Weiner, Michael W.; Aisen, Paul; Petersen, Ronald; Jack, Clifford R.; Jagust, William; Trojanowki, John Q.; Toga, Arthur W.; Beckett, Laurel; Green, Robert C.; Saykin, Andrew J.; [...]Anatomically interpretable deep learning of brain age captures domain-specific cognitive impairmentView onlineSchließen
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Published in: Proceedings of the National Academy of Sciences
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Iturria-Medina, Y.; Sotero, R. C.; Toussaint, P. J.; Mateos-Pérez, J. M.; Evans, A. C.; Weiner, Michael W.; Aisen, Paul; Petersen, Ronald; Jack, Clifford R.; Jagust, William; Trojanowki, John Q.; Toga, Arthur W.; Beckett, Laurel; Green, Robert C.; Saykin, Andrew J.; Morris, John; Shaw, Leslie M.; Khachaturian, Zaven; Sorensen, Greg; Kuller, Lew; Raichle, Marc; Paul, Steven; Davies, Peter; Fillit, Howard; [...]Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysisView onlineSchließen
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Published in: Nature Communications
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Erickson, Pontus; Simrén, Joel; Brum, Wagner S.; Ennis, Gilda E.; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Langhough, Rebecca; Jonaitis, Erin M.; Van Hulle, Carol A.; Betthauser, Tobey J.; Carlsson, Cynthia M.; Asthana, Sanjay; Ashton, Nicholas J.; Johnson, Sterling C.; Shaw, Leslie M.; Blennow, Kaj; Andreasson, Ulf; Bendlin, Barbara B.; Zetterberg, Henrik; Weiner, Michael; Aisen, Paul; Petersen, Ronald; Jack, Clifford R.; Jagust, William; [...]Prevalence and Clinical Implications of a β-Amyloid–Negative, Tau-Positive Cerebrospinal Fluid Biomarker Profile in Alzheimer DiseaseView onlineSchließen
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Published in: JAMA Neurology
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Yang, Zhijian; Nasrallah, Ilya M.; Shou, Haochang; Wen, Junhao; Doshi, Jimit; Habes, Mohamad; Erus, Guray; Abdulkadir, Ahmed; Resnick, Susan M.; Albert, Marilyn S.; Maruff, Paul; Fripp, Jurgen; Morris, John C.; Wolk, David A.; Davatzikos, Christos; Fan, Yong; Bashyam, Vishnu; Mamouiran, Elizabeth; Melhem, Randa; Pomponio, Raymond; Sahoo, Dushyant; Ashish, Singh; Skampardoni, Ioanna; Sreepada, Lasya; [...]A deep learning framework identifies dimensional representations of Alzheimer’s Disease from brain structureView onlineSchließen
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Published in: Nature Communications
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Zhou, Xiaopu; Chen, Yu; Ip, Fanny C. F.; Jiang, Yuanbing; Cao, Han; Lv, Ge; Zhong, Huan; Chen, Jiahang; Ye, Tao; Chen, Yuewen; Zhang, Yulin; Ma, Shuangshuang; Lo, Ronnie M. N.; Tong, Estella P. S.; Weiner, Michael W.; Aisen, Paul; Petersen, Ronald; Jack, Clifford R.; Jagust, William; Trojanowski, John Q.; Toga, Arthur W.; Beckett, Laurel; Green, Robert C.; Saykin, Andrew J.; [...]Deep learning-based polygenic risk analysis for Alzheimer’s disease predictionView onlineSchließen
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Published in: Communications Medicine
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Wen, Junhao; Fu, Cynthia H. Y.; Tosun, Duygu; Veturi, Yogasudha; Yang, Zhijian; Abdulkadir, Ahmed; Mamourian, Elizabeth; Srinivasan, Dhivya; Skampardoni, Ioanna; Singh, Ashish; Nawani, Hema; Bao, Jingxuan; Erus, Guray; Shou, Haochang; Habes, Mohamad; Doshi, Jimit; Varol, Erdem; Mackin, R. Scott; Sotiras, Aristeidis; Fan, Yong; Saykin, Andrew J.; Sheline, Yvette I.; Shen, Li; Ritchie, Marylyn D.; [...]Characterizing Heterogeneity in Neuroimaging, Cognition, Clinical Symptoms, and Genetics Among Patients With Late-Life DepressionView onlineSchließen
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Published in: JAMA Psychiatry
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Milicic, Lidija; Vacher, Michael; Porter, Tenielle; Doré, Vincent; Burnham, Samantha C.; Bourgeat, Pierrick; Shishegar, Rosita; Doecke, James; Armstrong, Nicola J.; Tankard, Rick; Maruff, Paul; Masters, Colin L.; Rowe, Christopher C.; Villemagne, Victor L.; Laws, Simon M.; Weiner, Michael; Aisen, Paul; Petersen, Ronald; Jack, Clifford R.; Jagust, William; Trojanowki, John Q.; Toga, Arthur W.; Beckett, Laurel; Green, Robert C.; [...]Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volumeView onlineSchließen
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Published in: GeroScience
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Jiang, Jiehui; Sheng, Can; Chen, Guanqun; Liu, Chunhua; Jin, Shichen; Li, Lanlan; Jiang, Xueyan; Han, Ying; Weiner, Michael W.; Aisen, Paul; Petersen, Ronald; Jack, Clifford R.; Jagust, William; Trojanowski, John Q.; Toga, Arthur W.; Beckett, Laurel; Green, Robert C.; Saykin, Andrew J.; Morris, John; Shaw, Leslie M.; Khachaturian, Zaven; Sorensen, Greg; Kuller, Lew; Raichle, Marcus; [...]Glucose metabolism patterns: A potential index to characterize brain ageing and predict high conversion risk into cognitive impairmentView onlineSchließen
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Published in: GeroScience
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Fathian, Alireza; Jamali, Yousef; Raoufy, Mohammad Reza; Weiner, Michael W.; Schuf, Norbert; Rosen, Howard J.; Miller, Bruce L.; Neylan, Thomas; Hayes, Jacqueline; Finley, Shannon; Aisen, Paul; Khachaturian, Zaven; Thomas, Ronald G.; Donohue, Michael; Walter, Sarah; Gessert, Devon; Sather, Tamie; Jiminez, Gus; Thal, Leon; Brewer, James; Vanderswag, Helen; Fleisher, Adam; Davis, Melissa; Morrison, Rosemary; [...]The trend of disruption in the functional brain network topology of Alzheimer’s diseaseView onlineSchließen
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Published in: Scientific Reports
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Digma, Leonardino A; Madsen, John R; Rissman, Robert A; Jacobs, Diane M; Brewer, James B; Banks, Sarah J; Weiner, Michael; Aisen, Paul; Petersen, Ronald; Jack, Clifford R; Jagust, William; Trojanowki, John Q; Toga, Arthur W; Beckett, Laurel; Green, Robert C; Saykin, Andrew J; Morris, John; Shaw, Leslie M; Liu, Enchi; Montine, Tom; Thomas, Ronald G; Donohue, Michael; Walter, Sarah; Gessert, Devon; [...]Women can bear a bigger burden: ante- and post-mortem evidence for reserve in the face of tauView onlineSchließen
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Published in: Brain Communications
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Franzmeier, Nicolai; Rubinski, Anna; Neitzel, Julia; Ewers, Michael; Weiner, Michael W.; Aisen, Paul; Petersen, Ronald; Jack, Clifford R.; Jagust, William; Trojanowski, John Q.; Toga, Arthur W.; Beckett, Laurel; Green, Robert C.; Saykin, Andrew J.; Morris, John; Shaw, Leslie M.; Khachaturian, Zaven; Sorensen, Greg; Kuller, Lew; Raichle, Marcus; Paul, Steven; Davies, Peter; Fillit, Howard; Hefti, Franz; [...]The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memoryView onlineSchließen
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Published in: Nature Communications
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Zhou, Xiaopu; Chen, Yu; Mok, Kin Y.; Kwok, Timothy C. Y.; Mok, Vincent C. T.; Guo, Qihao; Ip, Fanny C.; Chen, Yuewen; Mullapudi, Nandita; Weiner, Michael W.; Aisen, Paul; Petersen, Ronald; Jack, Clifford R.; Jagust, William; Trojanowski, John Q.; Toga, Arthur W.; Beckett, Laurel; Green, Robert C.; Saykin, Andrew J.; Morris, John; Shaw, Leslie M.; Khachaturian, Zaven; Sorensen, Greg; Kuller, Lew; [...]Non-coding variability at the APOE locus contributes to the Alzheimer’s riskView onlineSchließen
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Published in: Nature Communications
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Kundu, Suprateek; Lukemire, Joshua; Wang, Yikai; Guo, Ying; Weiner, Michael W.; Schuff, Norbert; Rosen, Howard J.; Miller, Bruce L.; Neylan, Thomas; Hayes, Jacqueline; Finley, Shannon; Aisen, Paul; Khachaturian, Zaven; Thomas, Ronald G.; Donohue, Michael; Walter, Sarah; Gessert, Devon; Sather, Tamie; Jiminez, Gus; Thal, Leon; Brewer, James; Vanderswag, Helen; Fleisher, Adam; Davis, Melissa; [...]A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer’s Disease DataView onlineSchließen
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Published in: Scientific Reports
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Young, Alexandra L; Marinescu, Razvan V; Oxtoby, Neil P; Bocchetta, Martina; Yong, Keir; Firth, Nicholas C; Cash, David M; Thomas, David L; Dick, Katrina M; Cardoso, Jorge; van Swieten, John; Borroni, Barbara; Galimberti, Daniela; Masellis, Mario; Tartaglia, Maria Carmela; Rowe, James B; Graff, Caroline; Tagliavini, Fabrizio; Frisoni, Giovanni B; Laforce, Robert; Finger, Elizabeth; de Mendonça, Alexandre; Sorbi, Sandro; Warren, Jason D; [...]Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage InferenceView onlineSchließen
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Published in: Nature Communications
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Schmitz, Taylor W.; Nathan Spreng, R.; Weiner, Michael W.; Aisen, Paul; Petersen, Ronald; Jack, Clifford R.; Jagust, William; Trojanowki, John Q.; Toga, Arthur W.; Beckett, Laurel; Green, Robert C.; Saykin, Andrew J.; Morris, John; Shaw, Leslie M.; Khachaturian, Zaven; Sorensen, Greg; Kuller, Lew; Raichle, Marc; Paul, Steven; Davies, Peter; Fillit, Howard; Hefti, Franz; Holtzman, Davie; Mesulam, M Marcel; [...]Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer’s pathologyView onlineSchließen
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Published in: Nature Communications
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Ayton, Scott; Faux, Noel G.; Bush, Ashley I.; Weiner, Michael W.; Aisen, Paul; Petersen, Ronald; Jack, Clifford R.; Jagust, William; Trojanowki, John Q.; Toga, Arthur W.; Beckett, Laurel; Green, Robert C.; Saykin, Andrew J.; Morris, John; Shaw, Leslie M.; Khachaturian, Zaven; Sorensen, Greg; Kuller, Lew; Raichle, Marc; Paul, Steven; Davies, Peter; Fillit, Howard; Hefti, Franz; Holtzman, Davie; [...]Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOEView onlineSchließen
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Published in: Nature Communications
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Zhang, Qi; Fan, Chunqiu; Wang, Luyao; Li, Taoran; Wang, Min; Han, Ying; Jiang, Jiehui; Weiner, Michael W.; Aisen, Paul; Petersen, Ronald; Jack, Clifford R.; Jagust, William; Trojanowski, John Q.; Toga, Arthur W.; Beckett, Laurel; Green, Robert C.; Saykin, Andrew J.; Morris, John; Shaw, Leslie M.; Khachaturian, Zaven; Sorensen, Greg; Kuller, Lew; Raichle, Marcus; Paul, Steven; [...]Glucose metabolism in posterior cingulate cortex has supplementary value to predict the progression of cognitively unimpaired to dementia due to Alzheimer’s disease: an exploratory study of 18F-FDG-PETView onlineSchließen
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Published in: GeroScience