> Details

Gonneaud, Julie; Baria, Alex T.; Pichet Binette, Alexa; Gordon, Brian A.; Chhatwal, Jasmeer P.; Cruchaga, Carlos; Jucker, Mathias; Levin, Johannes; Salloway, Stephen; Farlow, Martin; Gauthier, Serge; Benzinger, Tammie L. S.; Morris, John C.; Bateman, Randall J.; Breitner, John C. S.; Poirier, Judes; Vachon-Presseau, Etienne; Villeneuve, Sylvia; Weiner, Michael; Rosen, Howard J.; Miller, Bruce L.; Aisen, Paul; Thomas, Ronald G.; Donohue, Michael; [...]

Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Reference
management

Bookmarks

Remove from
bookmarks

Share this on Whatsapp

Close

Bookmarks



You can manage bookmarks using lists, please log in to your user account for this.
  • Media type: E-Article
  • Title: Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease
  • Contributor: Gonneaud, Julie; Baria, Alex T.; Pichet Binette, Alexa; Gordon, Brian A.; Chhatwal, Jasmeer P.; Cruchaga, Carlos; Jucker, Mathias; Levin, Johannes; Salloway, Stephen; Farlow, Martin; Gauthier, Serge; Benzinger, Tammie L. S.; Morris, John C.; Bateman, Randall J.; Breitner, John C. S.; Poirier, Judes; Vachon-Presseau, Etienne; Villeneuve, Sylvia; Weiner, Michael; Rosen, Howard J.; Miller, Bruce L.; Aisen, Paul; Thomas, Ronald G.; Donohue, Michael; [...]
  • imprint: Springer Science and Business Media LLC, 2021
  • Published in: Nature Communications
  • Language: English
  • DOI: 10.1038/s41467-021-25492-9
  • ISSN: 2041-1723
  • Keywords: General Physics and Astronomy ; General Biochemistry, Genetics and Molecular Biology ; General Chemistry ; Multidisciplinary
  • Origination:
  • Footnote:
  • Description: <jats:title>Abstract</jats:title><jats:p>Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer’s disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI data, and assessed whether genetic determinants of AD, as well as beta-amyloid (Aβ) pathology, can accelerate brain aging. Using data from 1340 cognitively unimpaired participants between 18–94 years of age from multiple sites, we showed that topological properties of graphs constructed from rs-fMRI can predict chronological age across the lifespan. Application of our predictive model to the context of pre-clinical AD revealed that the pre-symptomatic phase of autosomal dominant AD includes acceleration of functional brain aging. This association was stronger in individuals having significant Aβ pathology.</jats:p>
  • Access State: Open Access